877932-98-4Relevant articles and documents
Process for the preparation of compounds having ACE inhibitory action and intermediates in said process
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, (2008/06/13)
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Decahydroisoquinoline carboxylic acids
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, (2008/06/13)
What are disclosed are aminoacid compounds of the formula STR1 wherein n is 0 or 1, and salts thereof, said compounds and salts having hypotensive properties; methods for making the compounds; pharmaceutical compositions containing the compounds or salts;
Process for preparing carboxyalkyl dipeptides
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, (2008/06/13)
Pharmaceutically active carboxyalkyl dipeptides such as enalapril, lisinopril and the like, are prepared from a starting amino acid such as L-alanine, by protecting the acid function of the amino acid with an alkyl silyl protecting group, while it is reacted with an α-halo ester, at its amino function. Subsequently, the silyl protectant is removed, and the acid group is reacted with the amino function of an appropriate amino acid such as L-proline, to form the dipeptide product.