878276-92-7

Basic information

• Product Name: Quinoline, 4-chloro-6-(4-chlorophenyl)-
• CAS NO: 878276-92-7
• Molecular Formula: C15H9Cl2N
• Molecular Weight: 274.149
• Mol File: 878276-92-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Quinoline, 4-chloro-6-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoline, 4-chloro-6-(4-chlorophenyl)-(878276-92-7)
• EPA Substance Registry System: Quinoline, 4-chloro-6-(4-chlorophenyl)-(878276-92-7)

Safety Data

• Hazardous Substances Data: 878276-92-7(Hazardous Substances Data)

Upstream product

• 106-39-8 bromochlorobenzene 
• 65340-70-7 6-bromo-4-chloroquinoline 
• 195062-61-4 4-chlorophenylboronic acid pinacol ester 
• 1679-18-1 4-Chlorophenylboronic acid 
• 40107-07-1 4-chloro-6-iodo-quinoline 

Downstream Products

• 1245921-76-9 C₂₃H₁₉ClN₂O 
• 1245921-77-0 C₂₂H₁₄ClN₃ 
• 1245921-73-6 C₂₂H₁₅ClN₂O₂ 
• 1245921-74-7 C₂₁H₁₅ClN₂O 
• 1245921-84-9 C₂₁H₁₃Cl₂FN₂ 
• 1245921-78-1 C₂₇H₂₅ClN₄O 
• 1245921-75-8 C₂₅H₂₂ClN₃O 

Relevant articles and documents

A novel protocol for the one-pot borylation/Suzuki reaction provides easy access to hinge-binding groups for kinase inhibitors

The one-pot borylation/Suzuki reaction is a very efficient means of accessing cross-coupling products of two aryl-halide partners that generally requires the use of specific catalysts or ligands and/or relatively long reaction times. This new microwave-assisted method provides a quick one-pot borylation/Suzuki reaction protocol that we applied to the synthesis of various bi- or poly-aryl scaffolds, including a variety of aryl and heteroaryl ring systems and the core frameworks of kinase inhibitors vemurafenib and GDC-0879.

Successive substitution of halogen atoms in 4,6-dihaloquinolines in palladium-catalyzed reactions with amines and arylboronic acids

A procedure was developed for the synthesis of 4,6-diamino- and 4,6- or 6,4-arylaminoquinolines by palladium-catalyzed C-N- and/or C-C-cross-coupling of 6-bromo-4-chloroquinoline.