87833-80-5Relevant articles and documents
Aurora Kinase Modulators and Method of Use
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Paragraph 0547, (2014/11/27)
The present invention relates to chemical compounds having a general formula I wherein A1-8, D′, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.
AROMATIC AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME
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Page/Page column 27-28, (2009/01/20)
Provided are a novel aromatic amine derivative represented by the following general formula (1) and an organic electroluminescent device including an organic thin film formed of one or a plurality of layers including at least a light emitting layer interposed between a cathode and an anode, in which at least one layer of the organic thin film contains the aromatic amine derivative alone or as a component of a mixture, which contributes to suppressing molecular crystallization and improving yield in the production of an organic electroluminescent device, whereby an organic electroluminescent device having a long lifetime can be obtained, and the aromatic amine derivative is capable of realizing the organic electroluminescent device: where: R1 represents an aryl group or the like; a represents an integer of 0 to 4; b represents an integer of 1 to 3; and at least one of Ar1 to Ar4 represents a group represented by the following general formula (2): where Ar5 represents a fused aromatic ring group and Ar6 represents an aryl group or an aromatic heterocyclic group, where remaining groups of Ar1 to Ar4, none of which is represented by the general formula (2), each independently represent an aryl group or an aromatic heterocyclic group.
DIPROTONATION OF NITROARENES
Ohta, Toshiharu,Shudo, Koichi,Okamoto, Toshihiko
, p. 325 - 328 (2007/10/02)
Cryoscopic measurements shows that 1-nitronaphthalene is diprotonated in trifluoromethanesulfonic acid (TFSA).The diprotonated nitronaphthalenes are N,N-dihydroxyiminiumnaphthalenium dications, wich are fully characterised by UV, 1H-, 13/