87834-34-2

Basic information

• Product Name: ((S)-1-{2-[2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-ethyldisulfanyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester
• Synonyms: ((S)-1-{2-[2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-ethyldisulfanyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester
• CAS NO: 87834-34-2
• Molecular Weight: 646.872
• Mol File: 87834-34-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: ((S)-1-{2-[2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-ethyldisulfanyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: ((S)-1-{2-[2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-ethyldisulfanyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester(87834-34-2)
• EPA Substance Registry System: ((S)-1-{2-[2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-ethyldisulfanyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester(87834-34-2)

Safety Data

• Hazardous Substances Data: 87834-34-2(Hazardous Substances Data)

Upstream product

• 56-17-7 cystamine dihydrochioride 
• 3674-06-4 Boc-Phe-ONSu 
• 63-91-2 L-phenylalanine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 51-85-4 2,2'-dithio-bis[ethylamine] 

Relevant articles and documents

Cyclic biphalin analogues with a novel linker lead to potent agonist activities at mu, delta, and kappa opioid receptors

In an effort to improve biphalin's potency and efficacy at the μ-(MOR) and δ-opioid receptors (DOR), a series of cyclic biphalin analogues 1–5 with a cystamine or piperazine linker at the C-terminus were designed and synthesized by solution phase synthesi

Combinatorial synthesis through disulfide exchange: Discovery of potent psammaplin A type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA)

Psammaplin A is a symmetrical bromotyrosine-derived disulfide natural product isolated from the Psammaplysilla sponge, which exhibits in vitro antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). Inspired by the structure of this marine natural product, a combinatorial scrambling strategy for the construction of heterodimeric disulfide analogues was developed and applied to the construction of a 3828-membered library starting from 88 homodimeric disulfides. These psammaplin A analogues were screened directly against various gram positive bacterial strains leading to the discovery of a series of potent antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA). Among the most active leads derived from these studies are compounds 104, 105, 113, 115, 123, and 128. The present, catalytically-induced, disulfide exchange strategy may be extendable to other types of building blocks bearing thiol groups facilitating the construction of diverse discovery-oriented combinatorial libraries.