878381-37-4

Basic information

• Product Name: (3R)-2,2-dimethyl-3-hydroxycyclohexanone
• Synonyms: (3R)-2,2-dimethyl-3-hydroxycyclohexanone
• CAS NO: 878381-37-4
• Molecular Weight: 142.198
• Mol File: 878381-37-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (3R)-2,2-dimethyl-3-hydroxycyclohexanone(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-2,2-dimethyl-3-hydroxycyclohexanone(878381-37-4)
• EPA Substance Registry System: (3R)-2,2-dimethyl-3-hydroxycyclohexanone(878381-37-4)

Safety Data

• Hazardous Substances Data: 878381-37-4(Hazardous Substances Data)

Upstream product

• 562-13-0 2,2-dimethyl-1,3-cyclohexanedione 
• 1092452-05-5 (1R)-2,2-dimethyl-3-oxocyclohexyl acetate 

Relevant articles and documents

A Negishi cross-coupling reaction enables the total synthesis of (+)-stachyflin

We present a full account on the development of the total synthesis of the antiviral meroterpenoid (+)-stachyflin. The decalin subunit is rapidly accessed by an exo-selective Diels–Alder reaction, whereas the isonindolinone was synthesized via a highly efficient and practical de novo route starting from dimedone. A challenging sp2–sp3 Negishi cross-coupling reaction enabled construction of the crucial C15–C16 bond that connects the arene with the decalin subunit. For the final installation of the cis-decalin framework, a Lewis acid-catalyzed cyclization was applied.

Conversion of Torgov's synthesis of estrone into a highly enantioselective and efficient process

A very direct and efficient conversion of the achiral Torgov diketone into the natural form of O-methyl estrone is described. Copyright

Baker's yeast mediated mono-reduction of 1,3-cyclohexanediones bearing two identical C(2) substituents

Baker's yeast mediated transformation of a series of 1,3-cyclohexanediones with two identical substituents at C(2) was investigated and the results of the biotransformation were found to depend on the size of the substituents at C(2). 1,3-Cyclohexanediones with less sterically demanding C(2) substituents could be mono-reduced to provide the corresponding ketols in good yields and excellent enantiomeric excesses.