878809-88-2

Basic information

• Product Name: 4-((R)-4-(5-bromo-3-methylpyridin-2-yl)-2-methylpiperazin-1-yl)-6-(4-fluorophenyl)-2-((R)-2-methylpyrrolidin-1-yl)pyrimidine
• Synonyms: 4-((R)-4-(5-bromo-3-methylpyridin-2-yl)-2-methylpiperazin-1-yl)-6-(4-fluorophenyl)-2-((R)-2-methylpyrrolidin-1-yl)pyrimidine
• CAS NO: 878809-88-2
• Molecular Weight: 525.467
• Mol File: 878809-88-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-((R)-4-(5-bromo-3-methylpyridin-2-yl)-2-methylpiperazin-1-yl)-6-(4-fluorophenyl)-2-((R)-2-methylpyrrolidin-1-yl)pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((R)-4-(5-bromo-3-methylpyridin-2-yl)-2-methylpiperazin-1-yl)-6-(4-fluorophenyl)-2-((R)-2-methylpyrrolidin-1-yl)pyrimidine(878809-88-2)
• EPA Substance Registry System: 4-((R)-4-(5-bromo-3-methylpyridin-2-yl)-2-methylpiperazin-1-yl)-6-(4-fluorophenyl)-2-((R)-2-methylpyrrolidin-1-yl)pyrimidine(878809-88-2)

Safety Data

• Hazardous Substances Data: 878809-88-2(Hazardous Substances Data)

Upstream product

• 833472-84-7 2,4-dichloro-6-(4-fluorophenyl)pyrimidine 
• 878809-59-7 (R)-1-(5-bromo-3-methylpyridin-2-yl)-3-methylpiperazine 
• 1765-93-1 4-fluoroboronic acid 
• 75336-86-6 (2R)-methylpiperazine 
• 157007-54-0 2-(R)-methylpyrrolidine-1-carboxylic acid tert-butyl ester 
• 117607-13-3 (R)-2-methylpyrrolidine hydrobromide 

Relevant articles and documents

Development of a Multikilogram Scale Synthesis of a TRPV1 Antagonist

A highly efficient, regioselective five-step synthesis of the TRPV1 antagonist 1 is described. The coupling of piperazine 7 with dichloropyrimidine 8 proceeded via a regioselective Pd-mediated amination affording product 11 in excellent yield. Conversion of the penultimate product 14 afforded 1 through formation of a magnesium ate complex and trapping with CO2.