879-98-1

Basic information

• Product Name: 5-Guaiacolsulfonic acid
• Synonyms: guaiacol-5-sulfonic acid;2-Oxy-1-methoxy-benzol-sulfonsaeure-(4);3-Hydroxy-4-methoxy-benzolsulfonsaeure;hoeherschmelzende Guajacolsulfonsaeure;3-hydroxy-4-methoxybenzenesulfonic acid;3-hydroxy-4-methoxy-benzenesulfonic acid
• CAS NO: 879-98-1
• Molecular Formula: C7H8O5S
• Molecular Weight: 204.204
• Mol File: 879-98-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-Guaiacolsulfonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Guaiacolsulfonic acid(879-98-1)
• EPA Substance Registry System: 5-Guaiacolsulfonic acid(879-98-1)

Safety Data

• Hazardous Substances Data: 879-98-1(Hazardous Substances Data)

Usage

Uses

3-Hydroxy-4-methoxybenzenesulfonic Acid has been shown to have antitumor activity mice and rats inoculated with leukemia, adenocarcinoma, carcinosarcoma, and ovarian carcinoma cells.

Upstream product

• 613-70-7 2-methoxyphenyl acetate 
• 3743-23-5 5-chloro-2-methoxyphenol 
• 7664-93-9 sulfuric acid 
• 90-05-1 2-methoxy-phenol 
• 7134-09-0 3,4-dihydroxybenzenesulfonic acid 
• 74-88-4 methyl iodide 
• 553-17-3 bis(2-methoxy-phenyl)carbonate 
• 531-37-3 2-methoxyphenyl benzoate 
• 118161-14-1 4-Methoxy-3-sulfooxy-benzenesulfonic acid 

Downstream Products

• 118161-14-1 4-Methoxy-3-sulfooxy-benzenesulfonic acid 
• 7134-09-0 3,4-dihydroxybenzenesulfonic acid 
• 57421-55-3 6β-((R)-2-amino-2-phenyl-acetylamino)-penicillanic acid; 3(or 4)-hydroxy-4(or 3)-methoxy-benzenesulfonate 

Relevant articles and documents

COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 POLYPEPTIDES

The present disclosure relates to bifunctional compounds, which find utility as modulators of Interleukin-1 Receptor-Associated Kinase 4 (IRAK-4); the target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hppel-Lindau, cereblon, ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

Sulfonation and sulfation on reaction of 1,2-dihydroxybenzene and its methyl ethers in concentrated aqueous sulfuric acid

The homogeneous sulfonation of 1,2-dihydroxybenzene (1), its monomethyl (2) and dimethyl ether (3) in concentrated aqueous sulfuric acid at 25 deg C has been studied and isomer distributions, as well as rate coefficients for the sulfonation of 1-3 and their monosulfonic acids, have been determined.In 73.5-87.5percent H2SO4, 1 yields the 3- and 4-sulfonic acids in a ratio of 25:75, 2 yields the 4-, 5- and 6-sulfonic acids in a ratio of 46:36:18 in 73.5percent H2SO4 and 50:39:11 in 87.5percent H2SO4, whereas 3 yields only the 4-sulfonic acid.The remarkable absence of the 3-sulfonic acid (87.5percent H2SO4, the 4-sulfonic acid of 1 and the 5-sulfonic acid of 2 are present in part in the form of their hydrogen sulfate.In that acid region, the 3- and 4-sulfonic acids of 1 both yield the 3,5-disulfonic acid, the 4- and 6-sulfonic acids of 2 both yield the 4,6-disulfonic acid and the 4-sulfonic acid of 3 mainly yields the 4,6- together with some 4,5-disulfonic acid.