879088-40-1

Basic information

• Product Name: 2-(2-chloro-5-nitrophenyl)pyridine
• Synonyms: 2-(2-chloro-5-nitrophenyl)pyridine;4-Chloro-3-(pyridin-2-yl)nitrobenzene;2-(2-chloro-5-nitrophenyl)pyridine hydrochloride
• CAS NO: 879088-40-1
• Molecular Formula: C₁₁H₇ClN₂O₂
• Molecular Weight: 235
• Mol File: 879088-40-1.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(2-chloro-5-nitrophenyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-chloro-5-nitrophenyl)pyridine(879088-40-1)
• EPA Substance Registry System: 2-(2-chloro-5-nitrophenyl)pyridine(879088-40-1)

Safety Data

• Hazardous Substances Data: 879088-40-1(Hazardous Substances Data)

Usage

Description

2-(2-chloro-5-nitrophenyl)pyridine is an organic compound that serves as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of hedgehog pathway inhibitors.
Used in Pharmaceutical Industry:
2-(2-chloro-5-nitrophenyl)pyridine is used as a chemical intermediate for the synthesis of Vismondegib (V674700), a hedgehog pathway inhibitor. 2-(2-chloro-5-nitrophenyl)pyridine plays a crucial role in the development of medications targeting the hedgehog signaling pathway, which is implicated in various diseases, including cancer and congenital disorders.

Upstream product

• 16588-26-4 3-bromo-4-chloronitrobenzene 
• 74534-15-9 1-chloro-2-iodo-4-nitrobenzene 
• 192063-22-2 2-pyridyl zinc iodide 
• 4253-79-6 2-(3-nitrophenyl)pyridine 
• 110-86-1 pyridine 
• 694-59-7 pyridine N-oxide 
• 645-00-1 m-iodonitrobenzene 
• 103985-13-3 2-(3-nitrophenyl)pyridine 1-oxide 
• 6283-25-6 H₂NC₆H₃(Cl)NO₂ 
• 1008-89-5 2-phenylpyridine 
• 23082-50-0 2'-chloro-5'-nitroacetophenone 
• 21966-78-9 1,3-dimethyl-2-oxo-2,3-dihydropyrimidin-1-ium chloride 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 25784-91-2 2-chloro-5-nitrobenzoylchloride 

Downstream Products

• 879088-41-2 4-chloro-3-(pyridin-2-yl)benzeneamine 
• 879085-55-9 vismodegib 

Relevant articles and documents

Preparation method of vimodegil

The invention provides a preparation method of vimodegil. 2-chloro-5-nitroacetophenone is used as a raw material; 5-oxo-5-(2-chloro-5-nitrophenyl) n-valeraldehyde is prepared through an addition reaction between 2-chloro-5-nitroacetophenone and acrolein,

A [...] synthesis of intermediates method and application

The invention relates to a method for synthesizing intermediate [...] and application, which belongs to the field of organic synthesis, in particular to intermediate 2 - (2 - chloro - 5 - nitrophenyl) pyridine (i.e. compound A) preparation process, compri

Preparation method of vismodegib

The invention relates to a preparation method of vismodegib. The preparation method of the vismodegib comprises the following steps: taking 2-chlorine-5-nitroacetophenone as a starting material, performing 1,4-addition reaction on the 2-chlorine-5-nitroac