879275-33-9

Basic information

• Product Name: N-[(3R)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER
• Synonyms: N-[(3R)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER;tert-butyl N-[(3R)-piperidin-3-ylMethyl]carbaMate;tert-Butyl (R)-piperidin-3-ylmethylcarbamate;(R)-3-N-Boc-AMinoMethylpiperidine;tert-butyl N-[(3R)-piperidin-3-ylmethyl]carbamat;-tert-Butyl (piperidin-3-ylmethyl)
• CAS NO: 879275-33-9
• Molecular Formula: C₁₁H₂₂N₂O₂
• Molecular Weight: 214.307
• Mol File: 879275-33-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 321.8±15.0 °C(Predicted)
• Appearance: /
• Density: 0.981
• Storage Temp.: 2-8°C(protect from light)
• PKA: 12.71±0.46(Predicted)
• CAS DataBase Reference: N-[(3R)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(3R)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER(879275-33-9)
• EPA Substance Registry System: N-[(3R)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER(879275-33-9)

Safety Data

• Hazardous Substances Data: 879275-33-9(Hazardous Substances Data)

Usage

General Description

N-[(3R)-3-piperidinylmethyl]-carbamic acid 1,1-dimethylethyl ester is a chemical compound with the molecular formula C12H24N2O2. It is an ester derivative of the carbamic acid, containing a piperidine group and a tert-butyl group. N-[(3R)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. It has potential applications in the field of medicinal chemistry and drug development due to its ability to modify the pharmacokinetics and pharmacodynamics of certain drugs. Additionally, it may also have uses in the field of organic synthesis as a reagent or building block for creating more complex molecules.

InChI:InChI=1S/C11H22N2O2/c1-11(2,3)15-10(14)13-8-9-5-4-6-12-7-9/h9,12H,4-8H2,1-3H3,(H,13,14)

Upstream product

• 142643-29-6 tert-butyl (piperidin-3-ylmethyl)carbamate 

Downstream Products

• 879275-42-0 2-(4-((S)-3-(aminomethyl)piperidin-1-yl)-7-methylquinazolin-2-yl)-3-fluorophenol 
• 1016167-77-3 C₂₇H₃₇N₇O₄ 
• 1391739-80-2 tert-butyl ((S)-1-((S)-1-(4-methylbenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate 
• 1615249-89-2 tert-butyl ((S)-1-((S)-1-(3,4-dichlorobenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate 
• 1615249-93-8 tert-butyl ((S)-1-((S)-1-(3-cyanobenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate 
• 1615250-02-6 tert-butyl ((S)-1-((S)-3-(4-methylbenzyl)-2-oxooxazolidine-4-carbonyl)piperidin-3-yl)methylcarbamate 
• 1615250-03-7 tert-butyl ((S)-1-((R)-3-(4-methylbenzyl)-2-oxothiazolidine-4-carbonyl)piperidin-3-yl)methylcarbamate 
• 1615249-83-6 tert-butyl ((S)-1-((S)-1-(4-chlorobenzyl)-5-oxopyrrolidine-2-carbonyl) piperidin-3-yl)methylcarbamate 
• 1615249-87-0 tert-butyl ((S)-1-((S)-1-(4-bromobenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate 
• 1615249-91-6 tert-butyl ((S)-1-((S)-1-(2,6-dichlorobenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate 
• 1615249-95-0 tert-butyl ((S)-1-((S)-1-(4-cyanobenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate 
• 1615250-04-8 tert-butyl ((S)-1-((R)-3-(4-methylbenzyl)thiazolidine-4-carbonyl)piperidin-3-yl)methylcarbamate 
• 1615250-05-9 tert-butyl ((S)-1-((R)-3-(4-methylbenzoyl)thiazolidine-4-carbonyl)piperidin-3-yl)methylcarbamate 
• 1615250-10-6 C₂₅H₃₇N₃O₄ 

Relevant articles and documents

CHIRAL 1-(4-METHYLPHENYLMETHYL)-5-OXO-{N-[(3-T-BUTOXYCARBONYL- AMINOMETHYL)]-PIPERIDIN-1-YL}-PYRROLIDINE-2-CARBOXAMIDES AS INHIBITORS OF COLLAGEN INDUCED PLATELET ACTIVATION AND ADHESION

Chiral l-(4-methylphenylmethyl)-5-oxo-{N-[(3-t-butoxycarbonyl-aminomethyl)]- piperidin-l-yl}-pyrrolidine-2-carboxamides as inhibitors of collagen induced platelet activation and adhesion The present invention provides chiral (2S)-l-(4-methylphenylmethyl)-5-oxo-(3S)-{N-[(3-t- butoxycarbonyl aminomethyl)]-piperidin-l-yl}-pyrrolidine-2-carboxamide, and (2S)-1-(4- methylphenylmethyl)-5-oxo-(3R)-{N-[(3-t-butoxycarbonyl amino methyl)]-piperidin-l-yl}- pyrrolidine-2-carboxamide of formula 6 and 7 respectively. The present invention also relates to use of these moieties as inhibitors of collagen induced platelet adhesion and aggregation mediated through collagen receptors. The present invention provides a process for preparation of chiral carboxamides of formula 6 and 7 using the process which has advantage to avoid any racemization at the a-carboxylic center, during N-alkylation. The reagent LiHMDS is used at low temperatures to furnish methyl N-(p- methylphenylmethyl)lpyroglutamate in good chiral purity.