879503-84-1

Basic information

• Product Name: Pyrazinecarboxamide, 6-chloro-N-(2-chloro-5-hydroxyphenyl)-
• CAS NO: 879503-84-1
• Molecular Formula: C11H7Cl2N3O2
• Molecular Weight: 284.101
• Mol File: 879503-84-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Pyrazinecarboxamide, 6-chloro-N-(2-chloro-5-hydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazinecarboxamide, 6-chloro-N-(2-chloro-5-hydroxyphenyl)-(879503-84-1)
• EPA Substance Registry System: Pyrazinecarboxamide, 6-chloro-N-(2-chloro-5-hydroxyphenyl)-(879503-84-1)

Safety Data

• Hazardous Substances Data: 879503-84-1(Hazardous Substances Data)

Upstream product

• 16026-77-0 3-amino-4-chlorophenol 
• 148673-71-6 6-chloropyrazine-2-carboxylic acid chloride 

Relevant articles and documents

Synthesis and antimycobacterial evaluation of substituted pyrazinecarboxamides

Unsubstituted, halogenated and/or alkylated pyrazine-2-carboxylic acid amides connected via -CONH- bridge with substituted anilines were synthesized using currently known synthetic pathways. The synthetic approach, analytical, spectroscopic, lipophilicity and biological data of 20 newly synthesized compounds are presented. Structure-activity relationships among the chemical structures, the antimycobacterial, antifungal, photosynthesis inhibiting and antialgal activity of the evaluated substituted N-phenylpyrazine-2-carboxamides are discussed. 5-tert-Butyl-6-chloro-N-(3-trifluoromethylphenyl)pyrazine-2-carboxamide (19) has shown the highest activity against Mycobacterium tuberculosis H37Rv (MIC = 3.13 μg/mL). The highest antifungal effect against Trichophyton mentagrophytes, the most susceptible fungal strain tested, was found for N-(3-trifluoromethylphenyl)pyrazine-2-carboxamide (14, MIC = 62.5 μmol/mL). The highest reduction of chlorophyll content in Chlorella vulgaris was found for pyrazine-2-carboxylic acid (3-trifluoromethylphenyl)amide (9, IC50 = 12.1 μmol/L).