88-00-6

Basic information

• Product Name: ethyl 2,4-dichloro-3-oxobutyrate
• Synonyms: ethyl 2,4-dichloro-3-oxobutyrate;2,4-Dichloro-3-oxobutyric acid ethyl ester;Einecs 201-789-6
• CAS NO: 88-00-6
• Molecular Formula: C₆H₈Cl₂O₃
• Molecular Weight: 199.03192
• EINECS: 201-789-6
• Mol File: 88-00-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 18-20 °C
• Boiling Point: 234.2°C at 760 mmHg
• Flash Point: 95.9°C
• Appearance: /
• Density: 1.315g/cm³
• Vapor Pressure: 0.0536mmHg at 25°C
• Refractive Index: 1.458
• PKA: 6.79±0.46(Predicted)
• CAS DataBase Reference: ethyl 2,4-dichloro-3-oxobutyrate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2,4-dichloro-3-oxobutyrate(88-00-6)
• EPA Substance Registry System: ethyl 2,4-dichloro-3-oxobutyrate(88-00-6)

Safety Data

• Hazardous Substances Data: 88-00-6(Hazardous Substances Data)

Usage

General Description

Ethyl 2,4-dichloro-3-oxobutyrate is a chemical compound with the molecular formula C6H7Cl2O3. It is an ester, which means it is derived from an organic acid and an alcohol. ethyl 2,4-dichloro-3-oxobutyrate is often used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also a key intermediate in the production of pesticides, herbicides, and insecticides. Ethyl 2,4-dichloro-3-oxobutyrate has been identified as a potential environmental and health hazard, and caution should be exercised when handling and using this chemical.

InChI:InChI=1/C6H8Cl2O3/c1-2-11-6(10)5(8)4(9)3-7/h5H,2-3H2,1H3

Upstream product

• 105-39-5 chloroacetic acid ethyl ester 
• 141-97-9 ethyl acetoacetate 
• 638-07-3 ethyl (2-chloroaceto)acetate 

Downstream Products

• 1286716-33-3 ethyl 6-bromo-8-hydroxy-2-((phenylthio)methyl)imidazo[1,2-a]pyridine-3-carboxylate 
• 1286716-36-6 ethyl 6-bromo-2-((4-fluorophenylthio)methyl)-8-hydroxyimidazo[1,2-a]pyridine-3-carboxylate 
• 1286716-34-4 ethyl 6-bromo-2-((4-chlorophenylthio)methyl)-8-hydroxyimidazo[1,2-a]pyridine-3-carboxylate 
• 1286716-37-7 ethyl 6-bromo-2-((4-bromophenylthio)methyl)-8-hydroxyimidazo[1,2-a]pyridine-3-carboxylate 
• 1286716-35-5 ethyl 6-bromo-8-hydroxy-2-((p-tolylthio)methyl)imidazo[1,2-a]pyridine-3-carboxylate 
• 1286716-38-8 ethyl 6-bromo-8-hydroxy-2-((3-methoxyphenylthio)methyl)imidazo[1,2-a]pyridine-3-carboxylate 
• 1286716-10-6 ethyl 6-bromo-8-hydroxy-2-((phenylthio)methyl)-7-(pyrrolidin-1-ylmethyl)imidazo[1,2-a]pyridine-3-carboxylate 
• 1286716-12-8 ethyl 6-bromo-8-hydroxy-2-((phenylthio)methyl)-7-(piperidin-1-ylmethyl)imidazo[1,2-a]pyridine-3-carboxylate 
• 1286716-13-9 ethyl 6-bromo-8-hydroxy-7-((4-methylpiperazin-1-yl)methyl)-2-((phenylthio)methyl)imidazo[1,2-a]pyridine-3-carboxylate 
• 1286716-15-1 ethyl 6-bromo-7-((dimethylamino)methyl)-2-((4-fluorophenylthio)methyl)-8-hydroxyimidazo[1,2-a]pyridine-3-carboxylate 
• 1286716-17-3 ethyl 6-bromo-2-((4-fluorophenylthio)methyl)-8-hydroxy-7-(pyrrolidin-1-ylmethyl)imidazo[1,2-a]pyridine-3-carboxylate 
• 1286716-18-4 ethyl 6-bromo-2-((4-fluorophenylthio)methyl)-8-hydroxy-7-(piperidin-1-ylmethyl)imidazo[1,2-a]pyridine-3-carboxylate 
• 1286716-19-5 ethyl 6-bromo-2-((4-fluorophenylthio)methyl)-8-hydroxy-7-(morpholinomethyl)imidazo[1,2-a]pyridine-3-carboxylate 
• 1286716-20-8 ethyl 6-bromo-2-((4-chlorophenylthio)methyl)-8-hydroxy-7-(pyrrolidin-1-ylmethyl)imidazo[1,2-a]pyridine-3-carboxylate 

Relevant articles and documents

A 5 - chloro - 6 - (chloromethyl) uracil and its preparation method (by machine translation)

The present invention provides a 5 - chloro - 6 - (chloromethyl) uracil and its preparation method, comprises the following steps: (1), in order to-acetyl-acetic acid ethyl ester as the raw material, obtained by chlorination of the reaction process for preparing 4 - chloro acetyl ethyl acetate, 4 - chloro acetyl ethyl acetate through the chlorination reaction, to obtain 2, 4 - dichloro acetyl ethyl acetate; (2), the step (1) in the 2, 4 - dichloro-acetyl-acetic acid ethyl ester with urea in an acidic solvent, under the heating condition obtained by the reaction of 5 - chloro - 6 - (chloromethyl) uracil. The method has the raw materials are easy, simple operation, the method is reliable, low cost, and is suitable for industrial production and the like. The preparation of 5 - chloro - 6 - (chloromethyl) pyrimidine has the advantages of high purity in the urine, the purity is greater than 96%, can reach 99.4%. (by machine translation)

Synthesis and in-vitro anti-hepatitis B virus activity of ethyl 6-Bromo-8-hydroxyimidazo[1,2-a]pyridine-3-carboxylates

A series of ethyl 6-bromo-8-hydroxyimidazo[1,2-a]pyridine-3-carboxylate derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in HepG2.2.15 cells. Nearly half of the tested compounds were proved to be highly effective in inhibiting the replication of HBV DNA with IC50 values ranging from 1.3 to 9.1 μM. Among them, 10o and 10s were identified as the most promising compounds.