88-26-6Relevant articles and documents
Preparation method of antioxidant 330
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Paragraph 0027; 0029; 0031; 0033, (2021/01/29)
The invention relates to the technical field of chemical material processing, in particular to a synthetic method for preparing a hindered phenol antioxidant 330. The method comprises the following steps: reducing 3, 5-di-tert-butyl-4-hydroxybenzoic acid serving as an initial raw material into 3, 5-di-tert-butyl-4-hydroxybenzyl alcohol, and condensing the 3, 5-di-tert-butyl-4-hydroxybenzyl alcoholwith mesitylene under the action of an acid catalyst to generate the antioxidant 330. In the condensation reaction process, the phase transfer catalyst polyethylene glycol is utilized to improve thecatalytic effect of the concentrated sulfuric acid and reduce the consumption of the concentrated sulfuric acid, thereby having higher industrial value. The reaction yield is high, the optimal yield can reach 95%, the purity of the obtained reduction product is high, and in the industrial process, aftertreatment is simple. Therefore, the antioxidant 330 is synthesized by taking 3, 5-di-tert-butyl-4-hydroxybenzoic acid as an initial raw material and reducing 3, 5-di-tert-butyl-4-hydroxybenzoic acid into alcohol, and the method is a process route with relatively high industrial value.
Unusual transformation of 4-hydroxy/methoxybenzylic alcohols via C[sbnd]C ipso-substitution reaction using proton-exchanged montmorillonite as media
Chen, Dongyin,Chen, Xuan,Dong, Zezhong,Jiang, Nan,Li, Fei,Yun, Yangfang,Zhou, Yu
supporting information, (2020/11/12)
We present here proton-exchanged montmorillonite-mediated an unusual transformation of 4-hydroxy and 4-methoxybenzylic alcohols to form symmetrical benzylic ethers and diarylmethanes under mild conditions. Nuclear magnetic resonance spectroscopy and density functional theory calculations support a plausible mechanism, which includes a distinctive aromatic C[sbnd]C ipso-substitution reaction with a hydroxymethyl group as the C-based leaving group.
Synthetic method of 4-hydroxymethyl-2, 6-di-tert-butylphenol
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Paragraph 0007; 0008; 0009, (2018/10/26)
The invention provides a synthetic method of 4-hydroxymethyl-2, 6-di-tert-butylphenol. The synthetic method includes the steps of adopting the 2, 6-di-tert-butylphenol and paraformaldehyde or formaldehyde aqueous solution as starting material, adding solvent and catalysts, performing one-step reaction in a hydrothermal synthesis reactor and under a certain reaction temperature for a certain reaction time and then generating a target product. The synthetic method of 4-hydroxymethyl-2, 6-di-tert-butylphenol has the advantages of simple steps, convenient operation, green reaction process, and higher synthesis efficiency than an existing synthesis method.