88-49-3

Basic information

• Product Name: 4-CHLORO-2,5-DIMETHYLBENZENESULFONYL CHLORIDE
• Synonyms: 4-CHLORO-2,5-DIMETHYLBENZENESULPHONYL CHLORIDE;4-CHLORO-2,5-DIMETHYLBENZENESULFONYL CHLORIDE;5-chloro-p-xylene-2-sulphonyl chloride;Benzenesulfonylchloride, 4-chloro-2,5-dimethyl-
• CAS NO: 88-49-3
• Molecular Formula: C₈H₈Cl₂O₂S
• Molecular Weight: 239.12
• EINECS: 201-835-5
• Product Categories: Benzenesulfonyl chloride
• Mol File: 88-49-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 48 °C
• Boiling Point: 317.5 °C at 760 mmHg
• Flash Point: 145.8 °C
• Appearance: /
• Density: 1.401g/cm³
• Vapor Pressure: 0.000713mmHg at 25°C
• Refractive Index: 1.551
• Sensitive: Moisture Sensitive
• BRN: 2838165
• CAS DataBase Reference: 4-CHLORO-2,5-DIMETHYLBENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2,5-DIMETHYLBENZENESULFONYL CHLORIDE(88-49-3)
• EPA Substance Registry System: 4-CHLORO-2,5-DIMETHYLBENZENESULFONYL CHLORIDE(88-49-3)

Safety Data

• Hazard Codes: Xi,C
• Statements: 34-36
• Safety Statements: 26-36/37/39-45
• RIDADR: 3261
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 88-49-3(Hazardous Substances Data)

Usage

General Description

4-Chloro-2,5-Dimethylbenzenesulfonyl Chloride, also known as 4-chloro-2,5-dimethylbenzenesulfonyl chloride or 36477-04-2, is a chemical compound with the molecular formula C8H8Cl2O2S. 4-CHLORO-2,5-DIMETHYLBENZENESULFONYL CHLORIDE is characterized by its low melting point and high boiling point. It is primarily used in organic synthesis, where it serves as an intermediate in the manufacturing of other complex compounds. It is a slightly hazardous compound, and hence, should be handled with caution as it can cause irritation to the eyes, skin, and respiratory tract on exposure. Its stability and reactivity are typical of sulfonyl chlorides.

InChI:InChI=1/C8H8Cl2O2S/c1-5-4-8(13(10,11)12)6(2)3-7(5)9/h3-4H,1-2H3

Upstream product

• 27897-08-1 4-Amino-2,5-dimethylbenzenesulfonic Acid 
• 95-72-7 2-chloro-1,4-dimethyl-benzene 

Downstream Products

• 1186240-28-7 N-((1-(3-(1-(4-chloro-2,5-dimethylphenylsulfonyl)piperidin-2-yl)propanoyl)-4-(4-methylpiperazin-1-yl)piperidin-4-yl)methyl)acetamide 
• 1021204-82-9 3-[1-(4-chloro-2,5-dimethyl-phenylsulfonyl)-piperidin-2-yl]-propionic acid 
• 1361582-37-7 ethyl 3-(2-(4-chloro-2,5-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)propanoate 
• 1372617-16-7 C₁₆H₂₂ClNO₆S 
• 941816-76-8 (R)-2-(1-(4-chloro-2,5-dimethylphenylsulfonyl)-3-oxo-1,2,3,4-tetrahydropyrazin-2-yl)acetic acid 
• 1372617-67-8 C₁₈H₂₃ClN₂O₅S 
• 1372617-48-5 C₂₀H₃₁ClN₂O₇S 
• 680972-87-6 3-[3-(R,S)-(4-chloro-2,5-dimethylbenzenesulfonyl)-4-oxo-2,5-benzodiazepin-3-yl]-N-[2-(pyridin-4-yl)ethyl]acetamide 
• 1155860-60-8 C₂₁H₂₃Cl₃N₂O₃S 
• 1021204-95-4 methyl 3-[1-(4-chloro-2,5-dimethyl-phenylsulfonyl)-piperidin-2-yl]-propionate 
• 1190971-03-9 3-(1-(4-chloro-2,5-dimethylphenylsulfonyl)piperidin-2-yl)propionic acid ethyl ester 

Relevant articles and documents

Substituted Disulfonamide Compounds

Substituted disulfonamide compounds corresponding to formula I: In which R1, R2, R3, R4a, R4b, R5a, R5b, R8, R9a, R9b, R10, R11, a, b, s, t and A have defined meanings, pharmaceutical compositions containing one or more such compounds, processes for preparing such compounds, and a method of using such compounds for the treatment or inhibition of pain and/or other conditions mediated by the bradykinin receptor 1 (BR1).