880088-78-8

Basic information

• Product Name: 4-(Cyclopropylcarbonyl)-α,α-dimethylbenzeneacetic Acid Methyl Ester
• Synonyms: 4-(Cyclopropylcarbonyl)-α,α-dimethylbenzeneacetic Acid Methyl Ester
• CAS NO: 880088-78-8
• Molecular Formula: C₁₅H₁₈O₃
• Molecular Weight: 246.30162
• Product Categories: Aromatics;Intermediates
• Mol File: 880088-78-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(Cyclopropylcarbonyl)-α,α-dimethylbenzeneacetic Acid Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Cyclopropylcarbonyl)-α,α-dimethylbenzeneacetic Acid Methyl Ester(880088-78-8)
• EPA Substance Registry System: 4-(Cyclopropylcarbonyl)-α,α-dimethylbenzeneacetic Acid Methyl Ester(880088-78-8)

Safety Data

• Hazardous Substances Data: 880088-78-8(Hazardous Substances Data)

Usage

Description

4-(Cyclopropylcarbonyl)-α,α-dimethylbenzeneacetic Acid Methyl Ester is an organic compound that serves as an important intermediate in the synthesis of various pharmaceuticals. It is characterized by its unique molecular structure, which includes a cyclopropylcarbonyl group, two α,α-dimethyl substituents, and a methyl ester functional group.

Uses

Used in Pharmaceutical Industry:
4-(Cyclopropylcarbonyl)-α,α-dimethylbenzeneacetic Acid Methyl Ester is used as a key intermediate in the preparation of Carebastine, an antihistamine drug used for treating allergic symptoms such as sneezing, runny nose, and itchy eyes. Its unique structure allows for the development of effective medications with minimal side effects.
Additionally, it is also used in the preparation of Fexofenadine, another antihistamine medication used to treat allergy symptoms and prevent histamine release during allergic reactions. 4-(Cyclopropylcarbonyl)-α,α-dimethylbenzeneacetic Acid Methyl Ester's properties make it a valuable component in the synthesis of these medications, contributing to their efficacy and safety.

Upstream product

• 31469-15-5 1-methoxy-2-methyl-1-trimethylsiloxy-1-propene 
• 6952-89-2 (4-bromophenyl)(cyclopropyl)methanone 
• 67-56-1 methanol 
• 169280-21-1 2-[4-(4-chloro-butyryl)-phenyl]-2-methyl-propionic acid 
• 1195-98-8 2-methyl-2-phenylpropionitrile 
• 36293-05-7 2-methyl-2-phenylpropanoyl chloride 
• 140-29-4 phenylacetonitrile 

Relevant articles and documents

Synthetic method of fexofenadine intermediate

The invention provides a synthetic method of a fexofenadine intermediate 2-[4-[4-[4-(hydroxybenzhydryl)-1-piperidyl]-butyryl]phenyl]-2- methylmethacrylate. The method comprises the following steps: methylation of phenylacetonitrile which is used as a raw material, basic hydrolysis, weinreb amidation reaction, Friedel-crafts reaction, acid hydrolysis, esterification and condensation. The method has the following advantages: raw materials and auxiliary materials are cheap and easily available; yield is high; cost is low; there is no meta-isomer; and the method is suitable for industrial production.

Process for production of piperidine derivatives

Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: The processes involve reacting a compound of formula Ia, IIa or IIIa with isobutyrate or an isobutyrate equivalent.

Intermediates useful for the preparation of antihistaminic piperidine derivatives

The present invention is related to a novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of the formula wherein W represents -C(=O)- or -CH(OH)-; R1 represents hydrogen or hydroxy; R2 represents hydrogen; R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; n is an integer of from 1 to 5; m is an integer 0 or 1; R3 is -COOH or -COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof, with the proviso that where R1 and R2 are ta to form a second bond between the carbon R1 and R2 or where R1 represented hydroxy integer 0.