88014-15-7

Basic information

• Product Name: 2-(3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-ETHANOL
• Synonyms: 2-(3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-ETHANOL;2-(3,4-DIHYDROISOQUINOLIN-2(1H)-YL)ETHANOL;2-(3,4-dihydroisoquinolin-2(1H)-yl)ethanol(SALTDATA: FREE)
• CAS NO: 88014-15-7
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.24
• Mol File: 88014-15-7.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 309.1°C at 760 mmHg
• Flash Point: 156.5°C
• Appearance: /
• Density: 1.091g/cm³
• Vapor Pressure: 0.000282mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: 2-(3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-ETHANOL(88014-15-7)
• EPA Substance Registry System: 2-(3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-ETHANOL(88014-15-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 88014-15-7(Hazardous Substances Data)

Usage

General Description

2-(3,4-Dihydro-1H-isoquinolin-2-yl)-ethanol is a chemical compound with a molecular formula C12H15NO. It is a derivative of isoquinoline, a heterocyclic compound commonly found in many natural products and pharmaceuticals. 2-(3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-ETHANOL is classified as an isoquinolinol, and it contains both an isoquinoline ring and an ethyl alcohol functional group. 2-(3,4-Dihydro-1H-isoquinolin-2-yl)-ethanol is used in various research and drug development applications, especially in the study of neuropharmacology and central nervous system disorders. Its specific interactions and effects on biological systems are of interest to scientists and chemists, as it has the potential to serve as a starting point for the development of new drugs targeting neurological conditions.

InChI:InChI=1/C11H15NO/c13-8-7-12-6-5-10-3-1-2-4-11(10)9-12/h1-4,13H,5-9H2

Upstream product

• 75-21-8 oxirane 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 107-07-3 2-chloro-ethanol 
• 54423-94-8 2-(2-hydroxy-ethyl)-isoquinolinium; bromide 
• 88014-09-9 (3,4-dihydro-1H-isoquinolin-2-yl)-acetic acid ethyl ester 
• 94783-05-8 2-(2-Hydroxyethyl)-3,4-dihydroisochinoliniumbromid 
• 624-76-0 Iodoethanol 
• 540-51-2 2-bromoethanol 
• 95071-86-6 2,3,5,6-tetrahydro-10bH-oxazolo<2,3-a>isoquinoline 
• 119-65-3 isoquinoline 
• 18010-05-4 2-ethoxycarbonyl-methylisoquinolinium bromide 

Downstream Products

• 101728-74-9 2-[2-(3,4-dichloro-benzyloxy)-ethyl]-1,2,3,4-tetrahydro-isoquinoline 
• 101717-81-1 2-(2-benzyloxy-ethyl)-1,2,3,4-tetrahydro-isoquinoline 
• 101784-02-5 2-[2-(4-chloro-benzyloxy)-ethyl]-1,2,3,4-tetrahydro-isoquinoline 
• 102010-31-1 2-[2-(4-methoxy-benzyloxy)-ethyl]-1,2,3,4-tetrahydro-isoquinoline 
• 108839-62-9 2-[2-(2-methyl-benzyloxy)-ethyl]-1,2,3,4-tetrahydro-isoquinoline 
• 27160-30-1 2-(2-chloro-ethyl)-1,2,3,4-tetrahydro-isoquinoline; hydrochloride 

Relevant articles and documents

Iron oxide superparamagnetic nanocarriers bearing amphiphilic N-heterocyclic choline analogues as potential antimicrobial agents

Magnetic nanoparticles represent an advanced tool in biomedicine because they can be simultaneously functionalized and guided using a magnetic field. Iron oxide magnetic nanoparticles precoated with oleic acid and bearing novel antimicrobial N-heterocyclic choline analogues, namely O-, N- and O,N-bis-undecyl-substituted N-(2-hydroxyethyl)-1,2,3,4-tetrahydroisoquinolinium derivatives, have been obtained as potential biomedical agents for drug delivery and antimicrobial therapy. Structural and size determinations for the novel synthesized magnetic nanosystems were carried out based upon magnetogranulometry, dynamic light-scattering measurements and X-ray diffraction analysis. The most expected iron oxide core diameter was 6.2-10.5 nm. The magnetization analyses showed that the particles are superparamagnetic at room temperature. Aqueous magnetic fluids of the synthesized nanoparticles were examined in vitro concerning Gram-positive (Staphylococcus aureus MSCL 334, Bacillus cereus MSCL 330) and Gram-negative (Escherichia coli MSCL 332, Pseudomonas aeruginosa MSCL 331, Proteus mirabilis MSCL 590) bacterial strains and fungi (Candida albicans MSCL 378, Aspergillus niger MSCL 324). It was found that the samples have magnetic properties and possess antimicrobial activity. The minimum inhibitory concentration against S. aureus for the most active magnetic fluid was determined as 16 μg ml-1.

HETEROCYCLIC COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN

Provided herein are certain compounds and imaging agents useful for detecting a disease or condition associated with protein aggregation, especially huntingtin protein aggregation, compositions thereof, and methods of their use.

Silyl modification of biologically active compounds. 13. Synthesis, cytotoxicity and antibacterial action of N-methyl-N-(2-triorganylsiloxyethyl)-1, 2,3,4-tetrahydro(iso)quinolinium iodides

A series of N-methyl-N-(2-triorganylsiloxyethyl)-1,2,3,4-tetrahydro(iso) quinolinium iodides has been synthesized via dehydrocondensation reaction of N-(2-hydroxyethyl)-1,2,3,4-tetrahydroisoquinoline, N-(2-hydroxyethyl)-1,2,3,4- tetrahydroquinoline and 4,4-dimethyl-N-(2-hydroxyethyl)-4-sila-1,2,3,4- tetrahydroisoquinoline with trialkyl(aryl)hydrosilanes and subsequent alkylation, and characterized by 1H, 13C and 29Si NMR and mass spectroscopy. The biological activity data exhibited a marked enhancement of inhibitory activity against tumour cell lines and almost all the test bacterial/fungal strains in comparison with their 2-hydroxyethyl precursors. Cytotoxicity in the microgram range against HT-1080 (human fibrosarcoma) and MG-22A (mouse hepatoma) cancer cell lines was observed for most of compounds. Copyright