880489-31-6

Basic information

• Product Name: 1(2H)-Phthalazinone, 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-[[4-(methylsulfonyl)phenyl]methyl]-
• CAS NO: 880489-31-6
• Molecular Formula: C20H19N5O3S
• Molecular Weight: 409.469
• Mol File: 880489-31-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1(2H)-Phthalazinone, 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-[[4-(methylsulfonyl)phenyl]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1(2H)-Phthalazinone, 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-[[4-(methylsulfonyl)phenyl]methyl]-(880489-31-6)
• EPA Substance Registry System: 1(2H)-Phthalazinone, 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-[[4-(methylsulfonyl)phenyl]methyl]-(880489-31-6)

Safety Data

• Hazardous Substances Data: 880489-31-6(Hazardous Substances Data)

Upstream product

• 19064-73-4 4-bromo-2H-phthalazin-1-one 
• 1445-69-8 2,3-dihydrophthalazine-1,4-dione 
• 85-44-9 phthalic anhydride 

Relevant articles and documents

Phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of Aurora-A kinase

The inhibition of Aurora kinases in order to arrest mitosis and subsequently inhibit tumor growth via apoptosis of proliferating cells has generated significant discussion within the literature. We report a novel class of Aurora kinase inhibitors based upon a phthalazinone pyrazole scaffold. The development of the phthalazinone template resulted in a potent Aurora-A selective series of compounds (typically >1000-fold selectivity over Aurora-B) that display good pharmacological profiles with significantly improved oral bioavailability compared to the well studied Aurora inhibitor VX-680.