880549-34-8Relevant articles and documents
Uracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomers
Guo, Zhiqiang,Chen, Yongsheng,Huang, Charles Q.,Gross, Timothy D.,Pontillo, Joseph,Rowbottom, Martin W.,Saunders, John,Struthers, Scott,Tucci, Fabio C.,Xie, Qiu,Wade, Warren,Zhu, Yun-Fei,Wu, Dongpei,Chen, Chen
, p. 2519 - 2522 (2005)
Uracil derivatives were designed and synthesized to avoid atropisomers observed in the 6-methyluracils as antagonists of the human GnRH receptor. Optimization at the 1- and 5-positions of the uracil resulted in potent compounds such as 24 (Ki = 0.45 nM).