881-89-0

Basic information

• Product Name: phenyl 2-thiophenecarboxylate
• Synonyms: phenyl 2-thiophenecarboxylate
• CAS NO: 881-89-0
• Molecular Formula: C₁₁H₈O₂S
• Molecular Weight: 204.24502
• Mol File: 881-89-0.mol
• Article Data: 30

Chemical Properties

• Appearance: /
• CAS DataBase Reference: phenyl 2-thiophenecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl 2-thiophenecarboxylate(881-89-0)
• EPA Substance Registry System: phenyl 2-thiophenecarboxylate(881-89-0)

Safety Data

• Hazardous Substances Data: 881-89-0(Hazardous Substances Data)

Upstream product

• 5271-67-0 2-Thiophenecarbonyl chloride 
• 108-95-2 phenol 
• 30930-49-5 bis(2-thiophenecarbonyl) peroxide 
• 71-43-2 benzene 
• 527-72-0 2-thiophenylcarboxylic acid 
• 201230-82-2 carbon monoxide 
• 91228-44-3 2-thienylphenyliodonium tosylate 
• 591-50-4 iodobenzene 
• 108-86-1 bromobenzene 
• 108-90-7 chlorobenzene 
• 96-43-5 2-thienyl chloride 
• 98-03-3 thiophene-2-carbaldehyde 
• 98-80-6 phenylboronic acid 
• 2751-90-8 tetraphenylphosphonium bromide 

Downstream Products

• 20409-64-7 (2-hydroxyphenyl)(thiophen-2-yl)methanone 
• 97034-91-8 2-thienyl 2'-hydroxyphenyl ketone oxime 
• 97035-10-4 C₁₃H₁₁NO₃S 
• 833-50-1 2-phenylbenzo[d]oxazole 
• 10354-43-5 thiophene-2-carboxylic acid benzylamide 
• 56966-27-9 diphenyl(thiophen-2-yl)phosphine oxide 
• 58042-63-0 2-(p-tolylsulfanyl)thiophene 
• 89942-95-0 4-methyl-2-(2-thienyl)-thiazole 
• 96461-08-4 5-phenyl-2-(thiophen-2-yl)thiazole 
• 42140-95-4 2-(thiophen-2-yl)thiazole 
• 6846-13-5 N-phenyl-2-thiophenecarboxamide 

Relevant articles and documents

Transition-Metal-Free DMAP-Mediated Aromatic Esterification of Amides with Organoboronic Acids

A new, transition-metal-free, effective method for aromatic esterification of amides with organoboronic acids has been developed. A wide range of benzoate derivatives were obtained with yields ranging from moderate to good. The catalytic reaction shows a broad substrate scope and excellent functional group tolerance. Conceptually, DMAP mediates the reaction and is crucial for this transformation.

Conversion of esters to thioesters under mild conditions

We report conversion of esters to thioestersviaselective C-O bond cleavage/weak C-S bond formation under transition-metal-free conditions. The method is notable for a general and practical transition-metal-free system, broad substrate scope and excellent functional group tolerance. The strategy was successfully deployed in late-stage thioesterification, site-selective cross-coupling/thioesterification/decarbonylation and easy-to-handle gram scale thioesterification. Selectivity and computational studies were performed to gain insight into the formation of weak C-S bonds by C-O bond cleavage, which contrasts with the traditional trend of nucleophilic additions to carboxylic acid derivatives.

Palladium-Catalyzed Aerobic Oxidative Coupling of Amides with Arylboronic Acids by Cooperative Catalysis

The first fluoride and palladium co-catalyzed conversion of amide to ester through an aerobic oxidative coupling pathway is reported. This new approach presents a practical process that employs easily available oxygen and commercially available arylboronic acids as coupling partners, uses a wide range of N- tosylamides, and proceeds under mild reaction conditions. This protocol demonstrates broad functional group tolerance, and provides an alternative option to synthesize esters from N-tosylamides which obtained by simply N-functionalization of secondary amides.