881982-66-7Relevant articles and documents
Synthesis of 3-O-methylviridicatin analogues with improved anti-TNF-α properties
Ribeiro, Nigel,Tabaka, Helena,Peluso, Jean,Fetzer, Ludivine,Nebigil, Can,Dumont, Serge,Muller, Christian D.,Desaubry, Laurent
, p. 5523 - 5524 (2008/03/13)
We synthesized 3-O-methylviridicatin 1 and several analogues of this fungal metabolite. We showed that replacement of the methoxy moiety by a thiomethyl enhanced dramatically its ability to inhibit TNF-α secretion. These results strongly suggest that 4-phenyl-3-methylthioquinolinone 3 may provide the basis for the development of new anti-inflammatory agents.