881993-61-9Relevant articles and documents
Structure-based approach to nanomolar, water soluble matrix metalloproteinases inhibitors (MMPIs)
Attolino, Emanuele,Calderone, Vito,Dragoni, Elisa,Fragai, Marco,Richichi, Barbara,Luchinat, Claudio,Nativi, Cristina
supporting information; experimental part, p. 5919 - 5925 (2011/01/13)
N-Arylsulfonyl-based MMPs inhibitors (MMPIs) are among the most prominent inhibitors possessing nanomolar affinity. However, their poor bioavailability remains critical for the drug development of this family of molecules. The structural analysis of the c