88217-23-6 Usage
Description
Vibriobactin, a catecholate siderophore, is produced exclusively by Vibrio cholerae. It is composed of three molecules of 2,3-dihydroxybenzoate linked either directly or through L-threonine residues to the polyamine norspermidine. This unique structure allows vibriobactin to play a crucial role in the acquisition of iron, which is essential for the growth and virulence of Vibrio cholerae.
Uses
Used in Medical Research:
Vibriobactin is used as a subject of study in medical research for understanding the mechanisms of iron acquisition in pathogenic bacteria. Its unique structure and specificity to Vibrio cholerae make it an important molecule for investigating bacterial pathogenesis and developing potential therapeutic strategies against cholera and other bacterial infections.
Used in Drug Development:
Vibriobactin serves as a target for drug development aimed at disrupting the iron acquisition process in Vibrio cholerae. By inhibiting the production or function of vibriobactin, it may be possible to develop new antimicrobial agents that can effectively combat cholera and other infections caused by this bacterium.
Used in Diagnostics:
Vibriobactin can be utilized in the development of diagnostic tools for the detection of Vibrio cholerae in clinical samples. The presence of vibriobactin or its biosynthetic precursors may indicate an infection with this pathogen, allowing for rapid and accurate diagnosis of cholera and other related diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 88217-23-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,2,1 and 7 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 88217-23:
(7*8)+(6*8)+(5*2)+(4*1)+(3*7)+(2*2)+(1*3)=146
146 % 10 = 6
So 88217-23-6 is a valid CAS Registry Number.
InChI:InChI=1/C35H39N5O11/c1-18-26(38-33(50-18)21-9-4-12-24(42)29(21)45)32(48)37-15-7-17-40(16-6-14-36-31(47)20-8-3-11-23(41)28(20)44)35(49)27-19(2)51-34(39-27)22-10-5-13-25(43)30(22)46/h3-5,8-13,18-19,26-27,38-39,41-44H,6-7,14-17H2,1-2H3,(H,36,47)(H,37,48)/b33-21-,34-22-/t18-,19+,26+,27-/m0/s1
88217-23-6Relevant articles and documents
Convergent total syntheses of fluvibactin and vibriobactin using molybdenum(vi) oxide-catalyzed dehydrative cyclization as a key step
Sakakura, Akira,Umemura, Shuhei,Ishihara, Kazuaki
supporting information; experimental part, p. 3561 - 3563 (2009/02/05)
Efficient total syntheses of fluvibactin and vibriobactin have been achieved via molybdenum(vi) oxide-catalyzed dehydrative cyclization, Sb(OEt)3-catalyzed ester-amide transformation, and WSCI and HOAt-promoted dehydrative amide formation. The Royal Society of Chemistry.
Total synthesis of vibriobactin
Bergeron,Garlich,McManis
, p. 507 - 510 (2007/10/02)
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