88220-35-3

Basic information

• Product Name: Carbamic acid, (4-methylphenyl)-, 2-cyanophenyl ester
• CAS NO: 88220-35-3
• Molecular Formula: C15H12N2O2
• Molecular Weight: 252.272
• Mol File: 88220-35-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Carbamic acid, (4-methylphenyl)-, 2-cyanophenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (4-methylphenyl)-, 2-cyanophenyl ester(88220-35-3)
• EPA Substance Registry System: Carbamic acid, (4-methylphenyl)-, 2-cyanophenyl ester(88220-35-3)

Safety Data

• Hazardous Substances Data: 88220-35-3(Hazardous Substances Data)

Upstream product

• 611-20-1 salicylonitrile 
• 622-58-2 p-Tolylisocyanate 

Downstream Products

• 88220-45-5 2-(2-hydroxyphenyl)-6-methyl-4(3H)-quinazolinone 
• 7133-79-1 3-(4-methylphenyl)-2H-1,3-benzoxazine-2,4(3H)-dione 
• 88220-41-1 4-imino>-3-(4-methylphenyl)-2H-1,3-benzoxazin-2-one 
• 88220-43-3 4-<(4-methylphenyl)amino>-2H-1,3-benzoxazin-2-one 

Relevant articles and documents

Reactions of 2-Hydroxybenzonitrile with Isocyanates

Triethylamine catalyzes the reaction of 2-hydroxybenzonitrile (1) with arylisocyanates to form the corresponding carbamates 2a-c, as well as the cyclization of the latter compounds to either 4--3-aryl-2H-1,3-benzoxazin-2-ones 4a-c, or 4-arylamino-2H-1,3-benzoxazin-2-ones 7a-c, depending on the reaction temperature.Under analogous conditions, the carbamates obtained from 1 and 2-chloroethyl isocyanate, 3-chloropropyl isocyanate and ethyl isocyanatoacetate undergo a double cyclization yielding imidazo- and pyrimidobenzoxazinones 13a, b, 17.Upon heating in phenyl ether, compounds 7a-c, rearrange to 2-(2-hydroxyphenyl)-4(3H)-quinazolinones 10a-c.