88229-16-7

Basic information

• Product Name: N-Cyclopropyl 4-fluorobenzamide
• Synonyms: N-Cyclopropyl 4-fluorobenzamide
• CAS NO: 88229-16-7
• Molecular Formula: C₁₀H₁₀FNO
• Molecular Weight: 179.19
• Product Categories: blocks;Carboxes;FluoroCompounds
• Mol File: 88229-16-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-Cyclopropyl 4-fluorobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Cyclopropyl 4-fluorobenzamide(88229-16-7)
• EPA Substance Registry System: N-Cyclopropyl 4-fluorobenzamide(88229-16-7)

Safety Data

• Hazardous Substances Data: 88229-16-7(Hazardous Substances Data)

Usage

General Description

N-Cyclopropyl 4-fluorobenzamide is a chemical compound with the molecular formula C10H10FNO. It is a derivative of cyclopropylbenzamide and features a cyclopropyl group attached to the amide nitrogen and a fluorine atom at the para position of the benzene ring. N-Cyclopropyl 4-fluorobenzamide has been studied for its potential pharmaceutical applications, particularly as a potential ligand for cannabinoid receptors in the endocannabinoid system. Its structure and properties make it a candidate for further research and development as a potential drug candidate for treating various medical conditions.

Upstream product

• 403-43-0 4-fluorobenzoyl chloride 
• 765-30-0 Cyclopropylamine 
• 456-22-4 4-Fluorobenzoic acid 

Downstream Products

• 1246084-21-8 N-cyclopropyl-4-(4-((2,8-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)benzamide 
• 1246083-28-2 N-cyclopropyl-4-(4-((8-methoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)benzamide 
• 1018529-73-1 N-cyclopropyl-4-(piperazin-1-yl)benzamide 
• 1192139-71-1 N-(cyclopropyl)-4-fluorobenzimidoyl chloride 
• 70001-45-5 4-fluoro-N-isopropylbenzamide 

Relevant articles and documents

Diamine Synthesis via the Nitrogen-Directed Azidation of σ- And π-C-C Bonds

Diamines are essential building blocks for the synthesis of agrochemicals, drugs, and organic materials, yet their synthesis remains challenging, as both nitrogens need to be differentiated and diverse substitution patterns (1,2, 1,3, or 1,4) are required. We report herein a new strategy giving access to 1,2, 1,3, and 1,4 amido azides as orthogonally protected diamines based on the nitrogen-directed diazidation of alkenes, cyclopropanes, and cyclobutanes. Commercially available copper thiophene-2-carboxylate (CuTc, 2 mol %) as catalyst promoted the diazidation of both πand σ C-C bonds within 10 min in the presence of readily available oxidants and trimethylsilyl azide. Selective substitution of the formed α-amino azide by carbon nucleophiles (electron-rich aromatic, malonate, organosilicon, organoboron, organozinc, and organomagnesium compounds) was then achieved in a one-pot fashion, leading to the formation of 1,2-, 1,3-, and 1,4-diamines with the amino groups protected orthogonally as an amide/carbamate and an azide.

Synthesis of thiochromans via [3+3] annulation of aminocyclopropanes with thiophenols

We report the one-pot synthesis of 4-amino thiochromans using simple aminocyclopropanes and thiophenols through a formal [3+3] annulation reaction. This reaction proceeds under mild conditions with good functional group tolerance. The thiochroman core was

N-(R-cyclopropyl)fluorobenzimidoyl phosphonates

Reaction of N-(R-cyclopropyl)benzimidoyl chloride with triethyl phosphite has yielded the corresponding N-(R-cyclopropyl)-substituted benzimidoyl phosphonates existing predominantly in the E-configuration [E: Z ≈ (8-10): 1] at room temperature. 19/s