882303-63-1Relevant articles and documents
Real-time imaging of cancer cell generations and monitoring tumor growth using a nucleus-targeted red fluorescent probe
Wang, Lei,Xia, Qi,Liu, Ruiyuan,Qu, Jinqing
, p. 2340 - 2346 (2018)
Real-time and long-term nucleus labeling is of great significance for understanding and elucidating cellular and molecular processes in the life sciences, such as gene expression, replication, recombination, and repair, but remains challenging because of the lack of ideal imaging probes. Traditional commercial DNA stains for live-cell imaging either suffer from low water solubility, high cytotoxicity and photobleaching or have small Stokes shifts and low ultraviolet (UV) light excitation; these intrinsic drawbacks limit their utility. Here, a far-red DNA stain (PTB) is explored for in vitro long-term nucleus tracking and in vivo tumor growth monitoring. PTB exhibits a large Stokes shift (~110 nm), far-red emission (625 nm), and a 73.8-fold increase in fluorescence upon binding with DNA. Compared to currently used nucleus stains, PTB also displays low cytotoxicity and good photostability and biocompatibility. More importantly, the results of in vitro studies reveal that PTB can be tracked in stained HepG-2 cancer cells for up to 11 generations. Moreover, PTB demonstrates effective long-term (i.e., 21 days) tumor growth imaging in vivo. The combination of these remarkable properties makes PTB a promising far-red DNA stain.
Molecular engineering and synthesis of novel metal-free organic sensitizers with D-π-A-π-A architecture for DSSC applications: The effect of the anchoring group
Elmorsy, Mohamed R.,Su, Rui,Fadda, Ahmed A.,Etman,Tawfik, Eman H.,El-Shafei, Ahmed
, p. 121 - 130 (2018/05/28)
Herein, we report the design and synthesis of two metal-free organic sensitizers (MR-5 & MR-6) with a D-π-A-π-A architecture based on a trimethoxy benzene donor core carrying two different withdrawing/anchoring groups including cyanoacetic acid and rhodan
Small-molecule azomethines: Organic photovoltaics via Schiff base condensation chemistry
Petrus,Bouwer,Lafont,Athanasopoulos,Greenham,Dingemans
supporting information, p. 9474 - 9477 (2014/07/07)
Conjugated small-molecule azomethines for photovoltaic applications were prepared via Schiff base condensation chemistry. Bulk heterojunction (BHJ) devices exhibit efficiencies of 1.2% with MoOx as the hole-transporting layer. The versatility and simplicity of the chemistry is illustrated by preparing a photovoltaic device directly from the reaction mixture without any form of workup. This journal is the Partner Organisations 2014.