882531-32-0

Basic information

• Product Name: ethyl 4-[4-{(1H-benzimidazol-2-yl)methyl}piperazin-1-yl]benzoate
• Synonyms: ethyl 4-[4-{(1H-benzimidazol-2-yl)methyl}piperazin-1-yl]benzoate
• CAS NO: 882531-32-0
• Molecular Weight: 364.447
• Mol File: 882531-32-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 4-[4-{(1H-benzimidazol-2-yl)methyl}piperazin-1-yl]benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-[4-{(1H-benzimidazol-2-yl)methyl}piperazin-1-yl]benzoate(882531-32-0)
• EPA Substance Registry System: ethyl 4-[4-{(1H-benzimidazol-2-yl)methyl}piperazin-1-yl]benzoate(882531-32-0)

Safety Data

• Hazardous Substances Data: 882531-32-0(Hazardous Substances Data)

Upstream product

• 4857-04-9 2-chloromethyl-1H-benzimidazole 
• 80518-57-6 ethyl 4-(piperazin-1-yl)benzoate 
• 451-46-7 4-fluorobenzoic acid ethyl ester 

Downstream Products

• 882531-34-2 tert-butyl (2S)-benzenesulfonylamino-3-[4-{4-(1H-benzimidazol-2-yl)methylpiperazin-1-yl}benzoylamino]propionate 
• 882531-33-1 4-[4-{(1H-benzimidazol-2-yl)methyl}piperazin-1-yl]benzoic acid 

Relevant articles and documents

Tricyclic pharmacophore-based molecules as novel integrin αvβ3 antagonists. Part 1: Design and synthesis of a lead compound exhibiting αvβ3/ αIIbβ3 dual antagonistic activity

In order to generate novel compounds with integrin α vβ3-antagonistic activity together with antiplatelet activity, tricyclic pharmacophore-based molecules were designed and synthesized. Although piperazine-containing compounds initially prepared were selective αIIbβ3 antagonists, replacement of piperazine with piperidine furnished a potent αvβ3/ αIIbβ3 dual antagonist. Structure-activity relationship (SAR) studies provided clues for further development of tricyclic pharmacophore-based integrin antagonists.