88264-65-7

Basic information

• Product Name: DITHIOBIS[2-AMINO-4-METHYLPENTANE] DIHYDROCHLORIDE
• Synonyms: L-LEUCINETHIOL, OXIDIZED DIHYDROCHLORIDE;DITHIOBIS[2-AMINO-4-METHYLPENTANE] DIHYDROCHLORIDE;L-leucinethiol;dithiobis(2-amino-4-methylpentane);leucinthiol;L-Leucinethiol, oxidized
• CAS NO: 88264-65-7
• Molecular Formula: C12H30Cl2N2S2
• Molecular Weight: 337.42
• Mol File: 88264-65-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 181.8°C at 760 mmHg
• Flash Point: 63.8°C
• Appearance: /
• Density: 0.912g/cm³
• Vapor Pressure: 0.836mmHg at 25°C
• Refractive Index: 1.476
• Storage Temp.: −20°C
• CAS DataBase Reference: DITHIOBIS[2-AMINO-4-METHYLPENTANE] DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: DITHIOBIS[2-AMINO-4-METHYLPENTANE] DIHYDROCHLORIDE(88264-65-7)
• EPA Substance Registry System: DITHIOBIS[2-AMINO-4-METHYLPENTANE] DIHYDROCHLORIDE(88264-65-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 88264-65-7(Hazardous Substances Data)

Usage

Description

DITHIOBIS[2-AMINO-4-METHYLPENTANE] DIHYDROCHLORIDE is a chemical compound that can be reduced in vivo to L-leucinethiol. It is known for its potent inhibitory effects on leucine aminopeptidase, an enzyme involved in the hydrolysis of peptides.

Uses

Used in Pharmaceutical Industry:
DITHIOBIS[2-AMINO-4-METHYLPENTANE] DIHYDROCHLORIDE is used as a pharmaceutical agent for its inhibitory effects on leucine aminopeptidase. This property makes it a potential candidate for the development of drugs targeting various diseases and conditions where leucine aminopeptidase plays a significant role.
Used in Research Applications:
In the field of research, DITHIOBIS[2-AMINO-4-METHYLPENTANE] DIHYDROCHLORIDE serves as a valuable tool for studying the function and regulation of leucine aminopeptidase. Its potent inhibitory activity allows researchers to investigate the enzyme's role in biological processes and its potential as a therapeutic target.
Used in Drug Development:
DITHIOBIS[2-AMINO-4-METHYLPENTANE] DIHYDROCHLORIDE can be utilized in the development of novel drugs targeting leucine aminopeptidase. Its ability to inhibit the enzyme's activity makes it a promising starting point for designing new therapeutic agents that can modulate the enzyme's function and treat related diseases.

InChI:InChI=1/C6H15NS/c1-5(2)3-6(7)4-8/h5-6,8H,3-4,7H2,1-2H3/t6-/m0/s1

Upstream product

• 23852-57-5 (S)-2-(2-Methylpropyl)-aziridine 
• 13892-89-2 (S)-1-(bromomethyl)-3-methylbutylammonium bromide 
• 7533-40-6 (S)-2-amino-4-methylpentan-1-ol 

Downstream Products

• 101250-20-8 *,R^*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)thio>methyl>-3-methylbutyl>amino>methyl>-1-pyrrolidinecarboxylate 
• 101250-67-3 [S-(R*,R*)]-2-[[[1-[[[2-(1,1-Dimethylethoxy)-2-oxoethyl]thio]methyl]-3-methylbutyl]amino]methyl]-1-pyrrolidinecarboxylic acid, phenylmethyl ester 
• 101250-23-1 <2S-(R^*,R^*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)thio>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate 
• 101250-27-5 *,R^*)>-phenylmethyl 2-<<<1-<<(2-amino-2-oxoethyl)thio>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate 
• 101250-30-0 *,R^*)>-<<2-<<<1-(4-methoxybenzoyl)-2-pyrrolidinyl>carbonyl>amino>-4-methylpentyl>thio>acetate 
• 104360-88-5 ((S)-2-{[(S)-1-(4-Methoxy-benzoyl)-pyrrolidine-2-carbonyl]-amino}-4-methyl-pentylsulfanyl)-acetic acid tert-butyl ester 
• 101250-24-2 *,R^*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)thio>methyl>-3-methylbutyl>amino>carbonyl>-4-oxo-1-pyrrolidinecarboxylate 
• 101250-26-4 *,R^*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)thio>methyl>-3-methylbutyl>amino>carbonyl>-5-oxo-1-pyrrolidinecarboxylate 
• 101250-68-4 [S-(R*,R*)]-2-[[[1-[[(2-Amino-2-oxoethyl)thio]methyl]-3-methylbutyl][(1,1-Dimethylethoxy)carbonyl]amino]methyl]-1-[pyrrolidine]carboxylic acid, phenylmethyl ester 
• 101250-60-6 *,R^*)>-phenylmethyl 2-<<<1-<<<2-(1,1-dimethylethoxy)-2-oxoethyl>thio>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate 
• 101250-25-3 *,R^*)>-phenylmethyl 2-<<<1-<<(carboxymethyl)sulfonyl>methyl>-3-methylbutyl>amino>carbonyl>-1-pyrrolidinecarboxylate 
• 101250-63-9 (S)-2-((S)-1-tert-Butoxycarbonylmethylsulfanylmethyl-3-methyl-butylcarbamoyl)-5-oxo-pyrrolidine-1-carboxylic acid benzyl ester 
• 101250-61-7 (S)-2-((S)-1-tert-Butoxycarbonylmethylsulfanylmethyl-3-methyl-butylcarbamoyl)-4-oxo-pyrrolidine-1-carboxylic acid benzyl ester 
• 101250-65-1 (S)-2-((S)-1-tert-Butoxycarbonylmethanesulfonylmethyl-3-methyl-butylcarbamoyl)-pyrrolidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

Properties and Reactions of Substituted 1,2-Thiazetidine 1,1-Dioxides: Chiral Mono- and Bicyclic 1,2-Thiazetidine 1,1-Dioxides from α-Amino Acids

New chiral mono- and bicyclic β-sultams, valuable building blocks for drug synthesis, have been prepared from L-Ala, L-Val, L-Leu, L-Ile, L-Phe, L-Cys, L-Ser, L-Thr, and D-penicillamine by transformation of the COOH group into a methylsulfonyl chloride function, followed by cyclization under basic conditions. Selected properties, derivatives, and reactions of the β-sultams are described.

Modified tripeptides

Modified oxytocin-vasopressin di- or tri-peptides wherein an amide group is replaced by a group selected from STR1 --CH2 NH--, --CH2 O--, --CH2 S--, --CH2 SO--, --CH2 SO2 --, --CH2/su