88267-71-4

Basic information

• Product Name: 2-(1-ethoxycarbonylethyl)-1-phenyl-4(1H)-quinazolinone
• Synonyms: 2-(1-ethoxycarbonylethyl)-1-phenyl-4(1H)-quinazolinone
• CAS NO: 88267-71-4
• Molecular Weight: 322.364
• Mol File: 88267-71-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(1-ethoxycarbonylethyl)-1-phenyl-4(1H)-quinazolinone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-ethoxycarbonylethyl)-1-phenyl-4(1H)-quinazolinone(88267-71-4)
• EPA Substance Registry System: 2-(1-ethoxycarbonylethyl)-1-phenyl-4(1H)-quinazolinone(88267-71-4)

Safety Data

• Hazardous Substances Data: 88267-71-4(Hazardous Substances Data)

Upstream product

• 50496-34-9 ethyl 2-chloroformylpropanoate 
• 1211-19-4 2-phenylaminobenzamide 

Relevant articles and documents

Studies on 4(1H)-quinazolinones. 5. Synthesis and antiinflammatory activity of 4(1H)-quinazolinone derivatives

A number of new 4(1H)-quinazolinones were synthesized and evaluated in the carrageenin-induced paw edema test. Most of the compounds were obtained by the cyclization of the appropriately substituted anthranilamides with acid chlorides, followed by further chemical transformation. Structure-activity data suggest that 2-isopropyl-1-phenyl-, 2-cyclopropyl-1-phenyl-, and 1-isopropyl-2-phenyl-4(1H)-quinazolinones afford optimal potency and the presence of a halogen atom is preferred for activity. Adrenalectomy does not affect the antiinflammatory test results. The best result taking into account both efficacy and side effects was displayed by 1-isoproyl-(2-fluorophenyl)-4(1H)-quinazolinone.