882679-90-5 Usage
Description
5-Chloro-2-fluoronicotinaldehyde is an organic compound with the chemical formula C6H3ClFNO. It is a derivative of nicotinaldehyde, featuring a chloro and a fluoro substituent at the 5th and 2nd positions, respectively. 5-CHLORO-2-FLUORONICOTINALDEHYDE is known for its potential applications in the synthesis of various pharmaceuticals and agrochemicals.
Uses
Used in Pharmaceutical Industry:
5-Chloro-2-fluoronicotinaldehyde is used as a key intermediate in the synthesis of trisubstituted amine compounds, which serve as Cholesteryl Ester Transfer Protein (CETP) inhibitors. These inhibitors are valuable in the treatment of arteriosclerotic diseases, hyperlipidemia, dyslipidemia, and related conditions. By inhibiting CETP, these compounds help regulate the levels of cholesterol and other lipids in the bloodstream, thus managing and preventing cardiovascular issues.
Additionally, 5-chloro-2-fluoronicotinaldehyde may also be utilized in the development of other therapeutic agents targeting different medical conditions, owing to its unique structural features and reactivity. Its applications in drug discovery and medicinal chemistry can lead to the creation of novel and effective pharmaceuticals for various health concerns.
Check Digit Verification of cas no
The CAS Registry Mumber 882679-90-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,2,6,7 and 9 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 882679-90:
(8*8)+(7*8)+(6*2)+(5*6)+(4*7)+(3*9)+(2*9)+(1*0)=235
235 % 10 = 5
So 882679-90-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H3ClFNO/c7-5-1-4(3-10)6(8)9-2-5/h1-3H
882679-90-5Relevant articles and documents
BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT， AMELIORATION OR PREVENTION OF INFLUENZA
-
Page/Page column 65, (2017/12/27)
The present invention relates to a compound having the formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, codrug, cocrystal, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which is useful in treating, ameloriating or preventing influenza.
INHIBITORS OF INFLUENZA VIRUSES REPLICATION
-
Page/Page column 121, (2012/06/30)
Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.
