88277-50-3

Basic information

• Product Name: 3H-Cyclopenta[b]benzofuran-5-carboxylic acid, 7-broMo-3a,8b-dihydro-, cis-(-)-
• Synonyms: 3H-Cyclopenta[b]benzofuran-5-carboxylic acid, 7-broMo-3a,8b-dihydro-, cis-(-)-;3H-Cyclopenta[b]benzofuran-5-carboxylic acid, 7-bromo-3a,8b-dihydro-, (3aS,8bS)-
• CAS NO: 88277-50-3
• Molecular Formula: C₁₂H₉BrO₃
• Molecular Weight: 281.10206
• Mol File: 88277-50-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3H-Cyclopenta[b]benzofuran-5-carboxylic acid, 7-broMo-3a,8b-dihydro-, cis-(-)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-Cyclopenta[b]benzofuran-5-carboxylic acid, 7-broMo-3a,8b-dihydro-, cis-(-)-(88277-50-3)
• EPA Substance Registry System: 3H-Cyclopenta[b]benzofuran-5-carboxylic acid, 7-broMo-3a,8b-dihydro-, cis-(-)-(88277-50-3)

Safety Data

• Hazardous Substances Data: 88277-50-3(Hazardous Substances Data)

Usage

General Description

3H-Cyclopenta[b]benzofuran-5-carboxylic acid, 7-bromo-3a,8b-dihydro-, cis-(-)-is a chemical compound with a unique molecular structure. It contains a cyclopenta[b]benzofuran ring system with a carboxylic acid group at the fifth position and a bromine atom at the seventh position. The compound exists in a cis-(-)- isomeric form, indicating a specific spatial arrangement of its constituent atoms. This chemical may have potential applications in pharmaceutical or material science research due to its unique structure and properties.

Upstream product

• 124-38-9 carbon dioxide 
• 84599-02-0 3a,8b-cis-dihydro-3H-5,7-dibromocyclopentabenzofuran 
• 3784-04-1 potassium 2,4,6-tribromophenoxide 
• 84598-98-1 cis-1,4-bis(2,4,6-tribromophenoxy)cyclopent-2-ene 

Downstream Products

• 132203-89-5 (1S,2R,3aS,8bS)-7-bromo-2-hydroxy-1-(hydroxymethyl)-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-carboxylic acid methyl ester 
• 88277-19-4 methyl 4-((1S,2R,3aS,8bS)-2-hydroxy-1-(hydroxymethyl)-2,3,3a,8b-tetrahydro-1Hbenzo[b]cyclopenta[d]furan-5-yl)butanoate 
• 88277-23-0 4-((1R,2R,3aS,8bS)-2-Acetoxy-1-formyl-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-5-yl)-butyric acid methyl ester 
• 88295-11-8 4-((1S,2R,3aS,8bS)-2-Acetoxy-1-hydroxymethyl-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-5-yl)-butyric acid methyl ester 
• 113218-46-5 (1S,2R,3aS,8bS)-2-Hydroxy-1-hydroxymethyl-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-5-carboxylic acid methyl ester 
• 113218-45-4 methyl (1S,2R,3aS,8bS)-7-bromo-2-hydroxy-1-(hydroxymethyl)-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-5-carboxylic acid 
• 274250-61-2 (E)-4-((1S,2R,3aS,8bS)-2-Hydroxy-1-hydroxymethyl-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-5-yl)-but-3-enoic acid methyl ester 
• 132490-11-0 (1S,2R,3aS,8bS)-2-(Tetrahydro-pyran-2-yloxy)-1-(tetrahydro-pyran-2-yloxymethyl)-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-5-carbaldehyde 
• 132490-10-9 [(1S,2R,3aS,8bS)-2-(Tetrahydro-pyran-2-yloxy)-1-(tetrahydro-pyran-2-yloxymethyl)-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-5-yl]-methanol 
• 123670-64-4 (1S,2R,3aS,8bS)-2-(Tetrahydro-pyran-2-yloxy)-1-(tetrahydro-pyran-2-yloxymethyl)-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-5-carboxylic acid methyl ester 
• 88430-50-6 [1R,2R,3aS, 8bS]-(2,3,3a,8b-tetrahydro-2-hydroxyl-1-[(3S,4S)-3-hydroxyl-4-methyl-1-(E)-octen-6-ynyl]-1H-cyclopenta[b]benzofuran-5)-butanoic acid 
• 274250-76-9 4-[(1R,2R,3aS,8bS)-2-Hydroxy-1-((E)-(3R,4R)-3-hydroxy-4-methyl-oct-1-en-6-ynyl)-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-5-yl]-butyric acid methyl ester 
• 223556-67-0 4-[(1R,2R,3aS,8bS)-2-Hydroxy-1-((E)-(3R,4S)-3-hydroxy-4-methyl-oct-1-en-6-ynyl)-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-5-yl]-butyric acid methyl ester 
• 223556-68-1 4-[(1R,2R,3aS,8bS)-2-Hydroxy-1-((E)-(3S,4R)-3-hydroxy-4-methyl-oct-1-en-6-ynyl)-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-5-yl]-butyric acid methyl ester 

Relevant articles and documents

Synthesis method of beraprost sodium intermediate

The invention relates to a synthesis method of a Beraprost sodium intermediate (III). Cyclopentene and N-bromo-succinimide (NBS) carry out free radical reaction to obtain dibromocyclopentene; and dibromocyclopentene reacts with 2,4,6-tribromophenol to directly generate 3,5-bis(2,4,6-tribromophenoxyl) cyclopentene (compound I) through a one-pot method. Then through Grignard reactions, a compound (I) and a compound (II) are obtained. N-bromo-succinimide and a commercial product namely cyclopentene are taken as the raw materials to synthesize dibromocyclopentene, 170 DEG C cracking and ultralow temperature reactions (-40 to -30 DEG C) are avoided, the using of bromine is also avoided, the reaction conditions are milder, and the synthesis method is more environmentally friendly and is convenient for industrial production.

Synthesis of (+)-5,6,7-trinor-4,8-inter-m-phenylene PGI2

The titled compound, which is a stable and potent analog of prostacyclin, was synthesized from readily available 1,4-dibromocyclopentene via cyclopenta[b]benzofuran carboxylic acid 5.