88279-08-7

Basic information

• Product Name: 3-Ethoxy-1H-indazole
• Synonyms: 3-Ethoxy-1H-indazole
• CAS NO: 88279-08-7
• Molecular Formula: C9H10N2O
• Molecular Weight: 162.1885
• Mol File: 88279-08-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 83 °C
• Boiling Point: 321.3±15.0 °C(Predicted)
• Appearance: /
• Density: 1.196±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 13.44±0.40(Predicted)
• CAS DataBase Reference: 3-Ethoxy-1H-indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Ethoxy-1H-indazole(88279-08-7)
• EPA Substance Registry System: 3-Ethoxy-1H-indazole(88279-08-7)

Safety Data

• Hazardous Substances Data: 88279-08-7(Hazardous Substances Data)

Usage

General Description

3-Ethoxy-1H-indazole is a chemical compound with the molecular formula C9H10N2O. It is a derivative of indazole, which is a heterocyclic organic compound. 3-Ethoxy-1H-indazole is a pale yellow to light brown solid, which is soluble in organic solvents. It has potential pharmaceutical applications as a building block in the synthesis of various drug molecules. The compound has been studied for its potential use as an anti-cancer and anti-inflammatory agent. Additionally, it has shown promise as a ligand in metal-catalyzed reactions. 3-Ethoxy-1H-indazole has also been investigated as a potential precursor for the synthesis of various biologically active compounds.

Upstream product

• 368-39-8 triethyloxonium fluoroborate 
• 7364-25-2 3-indazolinone 
• 7364-25-2 1H-indazol-3-ol 
• 64-17-5 ethanol 
• 1441096-60-1 3-ethoxy-1-tosyl-1H-indazole 
• 825-60-5 benzimidic acid ethyl ester 

Relevant articles and documents

RhIII/CuII-cocatalyzed synthesis of 1H-indazoles through C-H amidation and N-N bond formation

Substituted 1H-indazoles can be formed from readily available arylimidates and organo azides by RhIII-catalyzed C-H activation/C-N bond formation and Cu-catalyzed N-N bond formation. For the first time the N-H-imidates are demonstrated to be go

1H- and 2H-Indazoles by Thermal and Photolytic Decomposition of o-Azidobenzoic Acid and o-Azidobenzaldehyde Derivatives

Ethyl o-azidobenzimidate (6) and o-azidobenzamidine (7) on thermolysis yield 3-ethoxy- (9; X=OEt) and 3-amino-1H-indazole (9; X=NH2), respectively.The former product is also obtained on irradiation of the imidate in methanol-tetrahydrofuran solution. 2-Aryl- and 2-heteroaryl-3-chloro-2H-indazoles have been prepared by the action of hot thionyl chloride on o-azidoanilides.The trichloro-2H-indazoles obtained by the action of phosphorus pentachloride on o-azidobenzanilide (12) and by the action of thionyl chloride on N-(o-azidobenzoyl)-2-aminopyridine have been identified as the 3,5,7-trichloro derivatives.The reductive dehalogenation, nitration, and reactivity of the halogen towards nucleophiles, of 3-chloro-2-phenyl-2H-indazole (19) are reported.A new practicable synthesis of o-azidobenzaldehyde (31; X=O) is described.Thermolysis of its phenylhydrazone and semicarbazone derivatives yields 2H-indazoles.