882999-50-0

Basic information

• Product Name: (2E)-3-(5-Fluoro-3-methyl-1H-indol-7-yl)-2-propenoic acid
• Synonyms: (2E)-3-(5-Fluoro-3-methyl-1H-indol-7-yl)-2-propenoic acid;(E)-3-(5-fluoro-3-methyl-1H-indol-7-yl)acrylic acid
• CAS NO: 882999-50-0
• Molecular Formula: C12H10FNO2
• Molecular Weight: 219.21
• Mol File: 882999-50-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 224℃
• Appearance: /
• Density: 1.387
• CAS DataBase Reference: (2E)-3-(5-Fluoro-3-methyl-1H-indol-7-yl)-2-propenoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-(5-Fluoro-3-methyl-1H-indol-7-yl)-2-propenoic acid(882999-50-0)
• EPA Substance Registry System: (2E)-3-(5-Fluoro-3-methyl-1H-indol-7-yl)-2-propenoic acid(882999-50-0)

Safety Data

• Hazardous Substances Data: 882999-50-0(Hazardous Substances Data)

Usage

General Description

The chemical "(2E)-3-(5-Fluoro-3-methyl-1H-indol-7-yl)-2-propenoic acid" is a compound with a complex molecular structure. It is a carboxylic acid derivative containing a fluorine-substituted indole ring. The chemical is categorized as a propenoic acid, indicating that it contains a propenoic acid moiety in its molecular structure. (2E)-3-(5-Fluoro-3-methyl-1H-indol-7-yl)-2-propenoic acid may have potential applications in the pharmaceutical or chemical industries, and further research may be needed to fully understand its properties and potential uses.

Upstream product

• 883001-24-9 7-bromo-5-fluoro-3-methyl-1H-indole 
• 79-10-7 acrylic acid 
• 882999-49-7 methyl (2E)-3-(5-fluoro-3-methyl-1H-indol-7-yl)acrylate 
• 946197-48-4 1-N-allyl-2,6-dibromo-4-fluoroaniline 
• 700-36-7 2-bromo-4-fluoronitrobenzene 
• 344-18-3 2,6-dibromo-4-fluoroaniline 

Downstream Products

• 883000-83-7 2,4,5-trifluoro-N-[(E)-3-(5-fluoro-3-methyl-1H-indol-7-yl)acryloyl]benzenesulfonamide 
• 883000-92-8 4-fluoro-N-[(E)-3-(5-fluoro-3-methyl-1H-indol-7-yl)acryloyl]benzenesulfonamide 
• 883000-84-8 3,4-difluoro-N-[(E)-3-(5-fluoro-3-methyl-1H-indol-7-yl)acryloyl]benzenesulfonamide 
• 883000-93-9 3,5-difluoro-N-[(E)-3-(5-fluoro-3-methyl-1H-indol-7-yl)acryloyl]benzenesulfonamide 
• 861238-35-9 [2H]-DG-041 

Relevant articles and documents

Structure - activity relationship studies leading to the identification of (2E)-3-[l-[(2,4-dichlorophenyl)methyl]-5-fluoro-3-methyl-lH-indol-7-yl]-N-[(4, 5-dichloro-2-thienyl)sulfonyl]-2-propenamide (DG-041), a potent and selective prostanoid EP3 receptor antagonist, as a novel antiplatelet agent that does not prolong bleeding

The EP3 receptor on the platelet mediates prostaglandin E 2 potentiation of thrombogenic coagonists including collagen and adenosine diphosphate (ADP). A pharmacophore driven approach led to the identification of diverse peri-substituted heterocycles as potent and selective EP3 receptor antagonists. A simultaneous chemical optimization and druglike assessment of prioritized molecules converged on a lead compound 50 (DG-041) that displayed favorable in vitro and functional activities as an inhibitor of human platelet aggregation. This agent is currently in human clinical trials for the treatment of atherothrombosis.

7-(ACRYLOYL) INDOLE COMPOSITIONS AND METHODS FOR MAKING AND USING SAME

The present invention is directed to pharmaceutical compositions of 7-(acryloyl) indoles, such as 4,5-Dichloro-thiophene-2-sulfonic acid [(E)-3-[1-(2,4-dichlorophenylmethyl)-5-fluoro-3-methyl-1H-indol-7-yl]-acryloyl]amide (DTSI). The invention is also dir

Sulfonamide peri-substituted bicyclics for occlusive artery disease

Acyl sulfonamide, peri-substituted, fused bicyclic ring compounds useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the general formula A representative example is: