88327-76-8

Basic information

• Product Name: 1-(Octahydro-pyrido[1,2-a]pyrazin-2-yl)-3-phenoxy-propan-2-ol
• Synonyms: 1-(Octahydro-pyrido[1,2-a]pyrazin-2-yl)-3-phenoxy-propan-2-ol
• CAS NO: 88327-76-8
• Molecular Weight: 290.406
• Mol File: 88327-76-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(Octahydro-pyrido[1,2-a]pyrazin-2-yl)-3-phenoxy-propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(Octahydro-pyrido[1,2-a]pyrazin-2-yl)-3-phenoxy-propan-2-ol(88327-76-8)
• EPA Substance Registry System: 1-(Octahydro-pyrido[1,2-a]pyrazin-2-yl)-3-phenoxy-propan-2-ol(88327-76-8)

Safety Data

• Hazardous Substances Data: 88327-76-8(Hazardous Substances Data)

Upstream product

• 122-60-1 Phenyl glycidyl ether 
• 4430-75-5 octahydro-1H-pyrido[1,2-a]pyrazine 
• 88327-69-9 1-(Hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-3-phenoxy-propan-2-ol 

Relevant articles and documents

Studies in Potential Filaricides: Part XIII - Synthesis of 1,4-Diazabicyclononanes, 1,4-Diazabicyclodecanes and 1,4-Diazabicycloundecanes as diethylcarbamazine Analogs

1,4-Diazabicyclononanes (13 - 20), 1,4-diazabicyclodecanes (21 - 28), 1,4-diazabicycloundecanes (29 - 34), 1,4-diazabicyclononan-5-ones (37 - 41) and 1,4-diazabicyclodecan-5-ones (42 - 44) having alkyl and acyl substituents at 4-position have been synthesized and evaluated for their filaricidal activity against Litomasoides carinii infection in cotton rats.Except 4-diethylcarbamoyl-1,4-diazabicyclononane (13), which exhibits significant activity, being about 3/5th as active as the standard diethylcarbamazine (DEC), none of the other compounds shows any activity against adult worms.The results have been rationalised in terms of critical bulk around the N-1 of the piperazine ring of DEC.From this work and earlier published results it appears that both axial and equatorial N-CH3 bonds in DEC are acceptable for activity.