88337-96-6

Basic information

• Product Name: 15-ACETOXY-3ALPHA,7ALPHA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-EN-8-ONE
• Synonyms: 3-D3-ACDON;3-ACETYL-D3-DEOXYNIVALENOL;15-ACDON;15-ACETYLVOMITOXIN;15-ADON;15-ACETYLDEOXYNIVALENOL;15-ACETOXY-3ALPHA,7ALPHA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-EN-8-ONE;15-O-ACETYL-4-DEOXYNIVALENOL
• CAS NO: 88337-96-6
• Molecular Formula: C₁₇H₂₂O₇
• Molecular Weight: 338.35
• EINECS: 200-835-2
• Product Categories: Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitor
• Mol File: 88337-96-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 518.8°C at 760 mmHg
• Flash Point: 2 °C
• Appearance: /
• Density: 1.42g/cm³
• Vapor Pressure: 6.23E-13mmHg at 25°C
• Refractive Index: 1.595
• Storage Temp.: 2-8°C
• PKA: 11.83±0.70(Predicted)
• CAS DataBase Reference: 15-ACETOXY-3ALPHA,7ALPHA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-EN-8-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 15-ACETOXY-3ALPHA,7ALPHA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-EN-8-ONE(88337-96-6)
• EPA Substance Registry System: 15-ACETOXY-3ALPHA,7ALPHA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-EN-8-ONE(88337-96-6)

Safety Data

• Hazard Codes: T,Xn,F
• Statements: 23/24/25-36-20/21/22-11
• Safety Statements: 36/37-45-26-16
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• RTECS: YD0155000
• HazardClass: 6.1(a)
• PackingGroup: I
• Hazardous Substances Data: 88337-96-6(Hazardous Substances Data)

Usage

Description

15-ACETOXY-3ALPHA,7ALPHA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-EN-8-ONE is a mycotoxin produced by the fungi Fusarium culmorum and Fusarium graminearum. It is a solid chemical compound that inhibits protein synthesis.

Uses

Used in Agriculture:
15-ACETOXY-3ALPHA,7ALPHA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-EN-8-ONE is used as a biopesticide for controlling fungal infections in crops. Its ability to inhibit protein synthesis in fungi helps protect plants from diseases caused by Fusarium species.
Used in Research:
15-ACETOXY-3ALPHA,7ALPHA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-EN-8-ONE is used as a research tool for studying the mechanisms of protein synthesis inhibition and the effects of mycotoxins on cellular processes. This knowledge can contribute to the development of new strategies for combating fungal infections and improving crop resistance.
Used in Food Industry:
15-ACETOXY-3ALPHA,7ALPHA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-EN-8-ONE can be used as a natural preservative in the food industry to prevent fungal contamination and extend the shelf life of food products. Its ability to inhibit fungal growth can help maintain food quality and safety.

InChI:InChI=1/C17H22O7/c1-8-4-11-16(6-18,13(21)12(8)20)15(3)5-10(23-9(2)19)14(24-11)17(15)7-22-17/h4,10-11,13-14,18,21H,5-7H2,1-3H3/t10-,11-,13-,14-,15-,16-,17+/m1/s1

Upstream product

• 108-24-7 acetic anhydride 
• 51481-10-8 vomitoxin hydrate 
• 64-19-7 acetic acid 
• 115032-23-0 C₂₂H₃₀O₈ 
• 50722-38-8 3α-acetoxy-7α,15-dihydroxy-12,13-epoxytrichothec-9-en-8-one 
• 72-89-9 S-acetyl coenzyme A 
• 51481-10-8 vomitoxin 
• 115825-62-2 3-O-acetyl-4-deoxynivalenol 

Downstream Products

• 51481-10-8 vomitoxin 

Relevant articles and documents

Sulfation of deoxynivalenol, its acetylated derivatives, and T2-toxin

The synthesis of several sulfates of trichothecene mycotoxins is presented. Deoxynivalenol (DON) and its acetylated derivatives were synthesized from 3-acetyldeoxynivalenol (3ADON) and used as substrate for sulfation in order to reach a series of five different DON-based sulfates as well as T2-toxin-3-sulfate. These substances are suspected to be formed during phase-II metabolism in plants and humans. The sulfation was performed using a sulfuryl imidazolium salt, which was synthesized prior to use. All protected intermediates and final products were characterized via NMR and will serve as reference materials for further investigations in the fields of toxicology and bioanalytics of mycotoxins.

4-O-acetylation and 3-O-acetylation of trichothecenes by trichothecene 15-O-acetyltransferase encoded by Fusarium Tri3

In the biosynthesis of Fusarium trichothecenes, the C-3 hydroxyl group of isotrichodermol must be acetylated by TRI101 for subsequent pathway genes to function. Despite the importance of this 3-O-acetylation step in biosynthesis, Tri101 is both physically and evolutionarily unrelated to other Tri genes in the trichothecene gene cluster. To gain insight into the evolutionary history of the cluster, we purified recombinant TRI3 (rTRI3), one of the two cluster gene-encoded trichothecene O-acetyltransferases, and examined to determine whether this 15-O-acetyltransferase can add an acetyl to the C-3 hydroxyl group of isotrichodermol. When a high concentration of rTRI3 was used in the assay (final concentration, 50μM), we observed 3-O-acetylation activity against isotrichodermol that was more than 105 times less efficient than the known 15-O-acetylation activity against 15-deacetylcalonectrin. The rTRI3 protein also exhibited 4-O-acetylation activity when nivalenol was used as a substrate; in addition to 15-acetylnivalenol, di-acetylated derivatives, 4,15- diacetylnivalenol, and, to a lesser extent, 3,15-diacetylnivalenol, were also detected at high enzyme concentrations. The significance of the trace trichothecene 3-O-acetyltransferase activity detected in rTRI3 is discussed in relation to the evolution of the trichothecene gene cluster.