883738-19-0

Basic information

• Product Name: tert-butyl 4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine-1-carboxylate
• Synonyms: tert-butyl 4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine-1-carboxylate;3-{[4-(tert-Butoxycarbonyl)piperazin-1-yl]methyl}benzeneboronicacid,pinacolester
• CAS NO: 883738-19-0
• Molecular Formula: C₂₂H₃₅BN₂O₄
• Molecular Weight: 402.35
• Mol File: 883738-19-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl 4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine-1-carboxylate(883738-19-0)
• EPA Substance Registry System: tert-butyl 4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine-1-carboxylate(883738-19-0)

Safety Data

• Hazardous Substances Data: 883738-19-0(Hazardous Substances Data)

Usage

Description

Tert-butyl 4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine-1-carboxylate is a complex organic chemical compound featuring a piperazine ring with a tert-butyl group, a benzyl group, and a carboxylate group. It also incorporates a tetramethyl-1,3,2-dioxaborolan-2-yl moiety, making it a versatile building block in organic synthesis and medicinal chemistry.

Uses

Used in Pharmaceutical Development:
Tert-butyl 4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine-1-carboxylate serves as a key intermediate in the synthesis of new pharmaceutical drugs. Its unique structure allows for the creation of molecules with potential therapeutic properties.
Used in Cancer Treatment Research:
In the field of oncology, this compound is utilized for the development of cancer treatments. Its structural features make it a candidate for the design of molecules that could target specific cancer cells, potentially leading to more effective therapies.
Used in Antiviral Drug Development:
tert-butyl 4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine-1-carboxylate also has potential applications in the creation of antiviral drugs. Its ability to be modified and combined with other molecules makes it a promising candidate for developing new antiviral agents to combat viral infections.
Used in Medicinal Chemistry:
In medicinal chemistry, tert-butyl 4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperazine-1-carboxylate is employed as a building block for designing and synthesizing a wide range of therapeutic agents. Its versatility in chemical reactions facilitates the exploration of new drug candidates for various diseases and conditions.

Upstream product

• 865314-27-8 tert-butyl 4-(3-bromobenzyl)piperazine-1-carboxylate 
• 73183-34-3 bis(pinacol)diborane 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 380151-86-0 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarboxaldehyde 
• 214360-74-4 2-(3-(bromomethyl)phenyl)-4,4,5,5,-tetramethyl-1,3,2-dioxaborolane 

Downstream Products

• 883734-27-8 N-(5-cyclopropyl-1H-pyrazol-3-yl)-7-(3-(piperazin-1-ylmethyl)phenyl)imidazo[1,2-f]pyrimidin-5-amine 
• 1316807-58-5 1-methanesulfonyl-4-(2'-nitro-biphenyl-3-ylmethyl)-piperazine 
• 1316807-60-9 (4-fluoro-phenyl)-[4-(3'-nitro-biphenyl-3-ylmethyl)-piperazin-1-yl]-methanone 
• 1316807-64-3 1-benzenesulfonyl-4-(3'-nitro-biphenyl-3-ylmethyl)-piperazine 
• 1316807-67-6 1-methanesulfonyl-4-(4'-nitro-biphenyl-3-ylmethyl)-piperazine 
• 1316807-95-0 (4-((3'-aminobiphenyl-3-yl)methyl)piperazin-1-yl)(4-fluorophenyl)methanone 
• 1316807-97-2 3'-((4-(phenylsulfonyl)piperazin-1-yl)methyl)biphenyl-3-amine 
• 1316808-00-0 3'-((4-(methylsulfonyl)piperazin-1-yl)methyl)biphenyl-4-amine 
• 1316808-18-0 4-cyano-N-(3'-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)biphenyl-2-yl)benzamide 
• 1316808-20-4 N-(3'-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)biphenyl-2-yl)thiophene-2-carboxamide 
• 1316808-21-5 methyl 3-(4-((2'-(cyclohexanecarboxamido)biphenyl-3-yl)methyl)piperazin-1-yl)-3-oxopropanoate 
• 1316808-23-7 N-(3'-((4-acetylpiperazin-1-yl)methyl)biphenyl-4-yl)furan-2-carboxamide 
• 1316808-25-9 3-methyl-N-(3'-((4-(methylsulfonyl)piperazin-1-yl)methyl)biphenyl-4-yl)butanamide 
• 1316808-38-4 (4-((3'-(1H-pyrrol-1-yl)biphenyl-3-yl)methyl)piperazin-1-yl)(4-fluorophenyl)methanone 

Relevant articles and documents

Microwave-mediated synthesis of an arylboronate library

A series of arylboronates has been synthesized from the reaction of 2-(2-, (3-, or (4-(bromomethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 1{1-3} respectively with a range of N-, S-, and O-nucleophiles, using microwave-mediated chemistry. For the synthesis of N- and S-substituted boronates, a supported base, PS-NMM, was employed, and many reactions were complete within 15 min. With O-nucleophiles, a mixture of tetrabutylammonium bromide, potassium carbonate, and sodium hydroxide was employed. The resulting aminomethyl, mercaptomethyl, or alkoxy-/phenoxymethyl-arylboronates were subjected to microwave-mediated Suzuki Miyaura coupling reactions to afford a range of biaryls in moderate to good yields. The X-ray structures of five boronates were determined.

KINASE INHIBITORS

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