884-12-8Relevant articles and documents
Facile catalyst-free synthesis of 2-vinylquinolines via a direct deamination reaction occurring during Mannich synthesis
Xiao, Jichao,Huang, Ye,Song, Zilan,Feng, Wenhua
, p. 99095 - 99098 (2015/12/04)
A facile catalyst-free method for the synthesis of 2-vinylquinolines via a direct deamination reaction during Mannich synthesis has been developed. Instantaneous hydrogen transfer via a six-membered ring intermediate is proposed as a key step for the direct deamination reaction. This reaction strategy tolerates a broad substrate scope and provides a highly efficient way to synthesize 2-vinylquinolines with adequate yields.
Microwave-assisted regioselective synthesis of β-aminoketones via the Mannich reaction
Gadhwal,Baruah,Prajapati,Sandhu
, p. 341 - 342 (2007/10/03)
A new and efficient method for the regioselective synthesis of β- aminoketones has been achieved by a simple reaction of formaldehyde, a secondary amine and a ketone under microwave irradiation.
A modified Mannich reaction using 1,3-dioxolane
Sumita,Koumori,Ohno
, p. 1676 - 1678 (2007/10/02)
Mannich reaction of ketones using 1,3-dioxolane instead of formaldehyde, paraformaldehyde, or 1,3,5-trioxane afforded the corresponding Mannich bases in high yields. Under the same conditions the aminomethylation of aromatics did not proceed but the intramolecular aminomethylation, like a Pictet-Spengler type reaction, proceeded smoothly.
