884504-18-1

Basic information

• Product Name: (4'-FLUORO[1,1'-BIPHENYL]-2-YL)METHANAMINE
• Synonyms: (4'-FLUORO[1,1'-BIPHENYL]-2-YL)METHANAMINE;1-(4'-FLUOROBIPHENYL-2-YL)METHYLAMINE;(4'-fluorobiphenyl-2-yl)methanamine;1-(4'-Fluorobiphenyl-2-yl)MethanaMine;4-(2-(aMinoMethyl)phenyl)-1-fluorobenzene;4'-Fluoro-2-biphenylMethylaMine, 97%;(4'-FLUORO[1,1'-BIPHENYL]-2-YL)METHAMINE
• CAS NO: 884504-18-1
• Molecular Formula: C13H12FN
• Molecular Weight: 201.24
• Mol File: 884504-18-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 334.6 °C at 760 mmHg
• Flash Point: 166.7 °C
• Appearance: /
• Density: 1.124
• Sensitive: Air Sensitive
• CAS DataBase Reference: (4'-FLUORO[1,1'-BIPHENYL]-2-YL)METHANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (4'-FLUORO[1,1'-BIPHENYL]-2-YL)METHANAMINE(884504-18-1)
• EPA Substance Registry System: (4'-FLUORO[1,1'-BIPHENYL]-2-YL)METHANAMINE(884504-18-1)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• HazardClass: IRRITANT
• Hazardous Substances Data: 884504-18-1(Hazardous Substances Data)

Usage

General Description

(4'-Fluoro[1,1'-biphenyl]-2-yl)methanamine is a chemical compound with the molecular formula C13H11FN. It is a derivative of biphenyl, which is a class of organic compounds consisting of two benzene rings connected by a single bond. (4'-FLUORO[1,1'-BIPHENYL]-2-YL)METHANAMINE contains a fluorine atom attached to the 4' position of the biphenyl ring and a methanamine group attached to the 2 position. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. The presence of the fluorine substituent in this compound can impart unique properties, making it useful in the development of new materials and drugs.

Upstream product

• 1189729-43-8 1-(4'-fluorobiphenyl-2-yl)methanamine hydrochloride 
• 89346-55-4 4'-fluoro-[1,1'-biphenyl]-2-carbonitrile 
• 1765-93-1 4-fluoroboronic acid 
• 4387-36-4 2-iodobenzonitrile 
• 162356-90-3 N-(tert-butoxycarbonyl)-2-bromobenzylamine 
• 3959-05-5 2-bromobenzylamine 

Relevant articles and documents

Synthesis of phenanthridines through iodine-supported intramolecular C-H amination and oxidation under visible light

Herein, we report a metal-free and step-economic synthesis of phenanthridines from 2-biarylmethanamines under mild conditions. The reaction involves iodine-supported intramolecular C-H amination and oxidation of 5,6-dihydrophenanthridine under air and benign visible light. The mechanism study reveals that visible light plays a key role in both these steps.

Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression

5-HT7 receptor (5-HT7R) is a promising target for the treatment of depression and neuropathic pain. 5-HT7R antagonists exhibited antidepressant effects, while the agonists produced strong anti-hyperalgesic effects. In our efforts to discover selective 5-HT 7R antagonists or agonists, N-biphenylylmethyl 2- methoxyphenylpiperazinylalkanamides 1 were designed, synthesized, and biologically evaluated against 5-HT7R. Among the synthesized compounds, N-2′-chlorobiphenylylmethyl 2- methoxyphenylpiperazinylpentanamide 1-8 showed the best binding affinity with a Ki value of 8.69 nM and it was verified as a novel antagonist according to functional assays. The compound 1-8 was very selective over 5-HT1DR, 5-HT2AR, 5-HT3R, 5-HT5AR and 5-HT6R and moderately selective over 5-HT1AR, 5-HT1BR and 5-HT2CR. The novel 5-HT7R antagonist 1-8 exhibited an antidepressant effect at a dose of 25 mg/kg in the forced swimming test in mice and showed a U-shaped dose-response curve which typically appears in 5-HT7R antagonists such as SB-269970 and lurasidone.