88462-64-0

Basic information

• Product Name: 3-Butyn-2-ol, 1-phenoxy-
• CAS NO: 88462-64-0
• Molecular Formula: C10H10O2
• Molecular Weight: 162.188
• Mol File: 88462-64-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 3-Butyn-2-ol, 1-phenoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Butyn-2-ol, 1-phenoxy-(88462-64-0)
• EPA Substance Registry System: 3-Butyn-2-ol, 1-phenoxy-(88462-64-0)

Safety Data

• Hazardous Substances Data: 88462-64-0(Hazardous Substances Data)

Upstream product

• 108-95-2 phenol 
• 4301-14-8 acetylenemagnesium bromide 
• 2120-70-9 2-phenoxyethanal 
• 74-86-2 acetylene 
• 122-59-8 2-phenoxyacetic acid 
• 6212-47-1 n-propyl phenoxyacetate 
• 2065-23-8 methyl 2-phenoxyacetate 
• 2555-49-9 phenoxyacetic acid ethyl ester 
• 111348-37-9 1-phenoxy-4-(trimethylsilyl)-3-butyn-2-ol 
• 122-99-6 2-Phenoxyethanol 

Downstream Products

• 88462-72-0 trans-3-Hydroxy-1-iodo-4-phenoxybut-1-ene 
• 108375-16-2 2-Iodo-3-hydroxy-4-phenoxy-1-butene 
• 126959-19-1 3-oxo-4-phenoxy-1-butyne 
• 88462-66-2 3-Trimethylsilyloxy-4-phenoxy-1-butyne 
• 139622-55-2 2-(1-Phenoxymethyl-prop-2-ynyloxy)-tetrahydro-pyran 

Relevant articles and documents

Drastic fluorine effect: Complete reversal of the selectivity in the Au-catalyzed hydroalkoxylation reaction of fluorinated haloalkynes

The gold-catalyzed hydration reaction of haloalkynes is highly regioselective producing 2-halomethylketones as the sole products. Herein, we document a drastic fluorine effect where the reaction of 1-halo-3,3-difluoroalkynes as substrates leads to a complete reversal of selectivity and produces 3,3-difluoroesters as the unique products.

Synthesis of 2-tetralone derivatives by Bi(OTf)3-catalyzed intramolecular hydroarylation/isomerization of propargyl alcohols

Compared to 1-tetralones, 2-tetralones are expensive, less stable, and difficult to synthesize. A concise Bi-catalyzed method was developed for the synthesis of 2-tetralones from 5-phenylpent-1-yn-3-ol derivatives. Diverse 2-tetralones were obtained in moderate to good yields under mild conditions.

Novel 6-alkyl and 6.8-dialkylbicyclo(4.2.0)octane derivatives

Compounds useful in treating or preventing gastrointestinal ulcers and in treating cardiovascular disorders such as thrombosis, hypertension and atherosclerosis are depicted in formulas (1), (2) and (3): STR1 wherein: A is --C C--, trans --HC=CH--, trans --CH=CHCH2 -- or --CH2 CH2 --; X is lower alkyl of 1-6 carbon atoms; Y is hydrogen, exo-(lower alkyl) or endo-(lower alkyl); n is an integer from 2-4; R1 is --CH2 OH, --CHO, --CO2 R or --CO2 H, and the olefin formed by the R1 (CH2)n CH= moiety is either (E) or (Z); R2 is hydrogen or methyl, or optionally --CH=CH2 when A is trans --CH=CHCH2 --; and R3 is linear or branched alkyl, alkenyl or alkynyl having 5-10 carbon atoms, STR2 --(CH2)m -phenyl or CH2 O-phenyl; in which each phenyl may be optionally substituted with lower alkyl, lower alkoxy, trifluoromethyl, or halogen. in which: a is an integer of 0, 1 or 2; b is an integer of 3-7; m is an integer of 0, 1 or 2; and R is STR3 wherein X' is STR4 in which each R4 is independently hydrogen or lower alkyl having 1-6 carbon atoms, or a pharmaceutically acceptable, non-toxic salt or ester thereof.