884867-93-0Relevant articles and documents
Superactivation of the botulinum neurotoxin serotype A light chain metalloprotease: A new wrinkle in botulinum neurotoxin
McAllister, Laura A.,Hixon, Mark S.,Kennedy, Jack P.,Dickerson, Tobin J.,Janda, Kim D.
, p. 4176 - 4177 (2006)
Small molecules based upon a 2-acylguanidine-5-phenyl thiophene scaffold that can activate the light chain metalloprotease of botulinum neurotoxin serotype A (BoNT LC/A) by an apparent reduction in Km are reported. On the basis of structure-act