885-75-6

Basic information

• Product Name: 2-amino-1,2-diphenylethanone
• Synonyms: 2-Amino-2-phenylacetophenone; Acetophenone, 2-amino-2-phenyl-; Desylamine; Ethanone, 2-amino-1,2-diphenyl-
• CAS NO: 885-75-6
• Molecular Formula: C₁₄H₁₃NO*ClH
• Molecular Weight: 211.2591
• Mol File: 885-75-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 363.6°C at 760 mmHg
• Flash Point: 173.7°C
• Density: 1.135g/cm³
• Vapor Pressure: 1.79E-05mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: 2-amino-1,2-diphenylethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-1,2-diphenylethanone(885-75-6)
• EPA Substance Registry System: 2-amino-1,2-diphenylethanone(885-75-6)

Safety Data

• Hazardous Substances Data: 885-75-6(Hazardous Substances Data)

Usage

Main properties

1. Chemical compound
2. Molecular formula: C14H13NO
3. Aromatic and carbonyl functional groups
4. Used in organic synthesis and pharmaceutical research

Specific content

1. Reagent in organic synthesis and pharmaceutical research
2. Known for aromatic and carbonyl functional groups
3. Studied for potential biological and pharmacological properties
4. Investigated for potential application in drug development
5. Demonstrated potential as an intermediate in the synthesis of various organic compounds

Upstream product

• 109-06-8 α-picoline 
• 14257-84-2 N-acetyl-α-phenylglycine 
• 93-97-0 benzoic acid anhydride 
• 3893-31-0 N-(2-oxo-1,2-diphenylethyl)acetamide 
• 32493-66-6 2-(2-oxo-1,2-diphenylethyl)isoindoline-1,3-dione 
• 801219-76-1 2-(diphenylphosphinamide)-1,2-diphenylethanone 
• 169899-58-5 2-(1-hydroxy-1-phenylmethyl)-4,5-dimethylthiazole 
• 5908-41-8 benzoyltrimethylsilane 
• 98837-46-8 N-benzylidenediphenylphosphinamide 
• 100-52-7 benzaldehyde 
• 904922-22-1 4,5-dimethyl-2-(phenyl-trimethylsilanyloxy-methyl)-thiazole 
• 1484-50-0 desyl bromide 
• 100-58-3 phenylmagnesium bromide 
• 119-53-9 2-hydroxy-2-phenylacetophenone 

Downstream Products

• 854228-62-9 2-amino-1,2-diphenyl-1-o-tolyl-ethanol 
• 3893-31-0 N-(2-oxo-1,2-diphenylethyl)acetamide 
• 530-36-9 erythro-2-amino-1,2-diphenylethanol 
• 530-36-9 threo-1,2-diphenyl-2-aminoethan-1-ol 
• 668-94-0 4,5-diphenyl-1H-imidazole 
• 102474-68-0 (1RS,2RS)-2-amino-1,2-diphenyl-1-p-tolyl-ethanol 
• 58417-78-0 α-Benzoylbenzyldithiocarbaminsaeure-methylester 
• 200802-49-9 4-Cyanomethyl-N-(2-oxo-1,2-diphenyl-ethyl)-benzamide 
• 6942-03-6 α-benzamidylbenzyl phenyl ketone 
• 15045-46-2 4-nitro-N-(2-oxo-1,2-diphenylethyl)benzamide 
• 200802-48-8 3-nitro-N-(2-oxo-1,2-diphenylethyl)benzamide 
• 200802-47-7 2-nitro-N-(2-oxo-1,2-diphenylethyl)benzamide 
• 97195-28-3 N-(2-oxo-1,2-diphenylethyl)formamide 
• 95947-45-8 2-(3-nitro-phenyl)-4,5-diphenyl-oxazole 

Relevant articles and documents

Asymmetric Transfer Hydrogenation: Dynamic Kinetic Resolution of α-Amino Ketones

A series of α-amino ketones were reduced using asymmetric transfer hydrogenation (ATH) through a dynamic kinetic resolution (DKR). The protecting group was matched to the reducing agent, and following optimization, a series of substrates were investigated, giving products in high diastereoselectivity, over 99% ee in several cases and full conversion. The methodology was applied to the enantioselective synthesis of an MDM2-p53 inhibitor precursor.

Catalytic additions of acylsilanes to imines: An acyl anion strategy for the direct synthesis of α-amino ketones

(Chemical Equation Presented) The addition of acylsilanes to imines catalyzed by neutral carbenes (or zwitterions) generated in situ from readily available thiazolium salts is described. The general reaction successfully utilizes acylsilanes as carbonyl anion precursors and is tolerant of a range of structural diversity on the acylsilane or imine electrophile. The overall reaction utilizes easily available precursors and directly accesses protected α-amino ketones in the correct oxidation state.

Pyrrolomorphinans as δ opioid receptor antagonists. The role of steric hindrance in conferring selectivity

A series of 2',3'-disubstituted pyrrolomorphinans (5a-i) were synthesized to determine the role of steric hindrance at μ and γ receptors in promoting δ opioid receptor antagonist selectivity. In smooth muscle preparations, five members of the series (5a-c,e,f) possessed K(e) values in the range 2-15 nM and were 6 selective. Since the unsubstituted analogue 4 possessed δ antagonist potency of similar magnitude, but was not δ selective, it is suggested that the 2',3'substitution confers δ selectivity by hindering the interaction of the pharmacophore at μ and γ receptors, while not affecting δ receptors.