88519-57-7

Basic information

• Product Name: N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE
• Synonyms: N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE;N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENE SULPHONAMIDE, HYDROCHLORIDE;OMEGA-13 HYDROCHLORIDE;W-13;W-13 HYDROCHLORIDE;N-(4-aminobutyl)-5-chloro-2-*naphthalenesulfonami;N-(4-AMINOBUTYL)-5-CHLORO-2- &;W-13 HYDROCHLORIDE CALMODULIN ANTAGONIST
• CAS NO: 88519-57-7
• Molecular Formula: C14H18Cl2N2O2S
• Molecular Weight: 349.28
• Product Categories: All Inhibitors;Inhibitors;Protein Kinase Inhibitors and Activators;Calcium signaling;Amines;Aromatics;Sulfur & Selenium Compounds
• Mol File: 88519-57-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 241-243°C
• Boiling Point: 523.4 °C at 760 mmHg
• Flash Point: 270.3 °C
• Appearance: white/powder
• Vapor Pressure: 2.6E-11mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: H2O: Stock solutions of 5 mM are recommended. These stocks shoul
• CAS DataBase Reference: N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE(88519-57-7)
• EPA Substance Registry System: N-(4-AMINOBUTYL)-5-CHLORO-2-NAPHTHALENESULFONAMIDE HYDROCHLORIDE(88519-57-7)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 88519-57-7(Hazardous Substances Data)

Usage

Description

W-13 is a naphthalenesulfonamide derivative that acts as a potent antagonist of calmodulin (IC50 = 22 μM) and is widely used to investigate Ca2+/calmodulin-regulated enzyme activities.

Chemical Properties

Beige Solid

Uses

Different sources of media describe the Uses of 88519-57-7 differently. You can refer to the following data:
1. W-13 is a naphthalenesulfonamide derivative that acts as a potent antagonist of calmodulin (IC50 = 22 μM) and is widely used to investigate Ca2+/calmodulin-regulated enzyme activities.
2. Calmodulin antagonist that binds to calmodulin and inhibits calcium-ion-calmodulin- regulated activities, including phosphodiesterase activation and myosin light chain kinase127, it is widely used to investigate Ca2+/calmodulin-regulated enzyme activities.

Biological Activity

Calmodulin antagonist (inhibits calmodulin activated PDE activity with an IC 50 of 68 μ M). Inhibits growth of tamoxifen-resistant breast cancer cells.

Biochem/physiol Actions

W-13 has also been shown to inhibit the transcytosis of IgA, recycling of transferrin and overall alter the endocytic pathway in Madin-Darby canine kidney cells.

InChI:InChI=1/C14H17ClN2O2S.ClH/c15-14-5-3-4-11-10-12(6-7-13(11)14)20(18,19)17-9-2-1-8-16;/h3-7,10,17H,1-2,8-9,16H2;1H

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