885223-63-2

Basic information

• Product Name: 5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide
• Synonyms: 5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide;N-Methoxy-N-methyl 5-bromo-2-chloronicotinamide;5-broMo-2-chloro-N-Methoxy-N-MethylnicotinaMide
• CAS NO: 885223-63-2
• Molecular Formula: C8H8BrClN2O2
• Molecular Weight: 279.51832
• Mol File: 885223-63-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide(885223-63-2)
• EPA Substance Registry System: 5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide(885223-63-2)

Safety Data

• Hazardous Substances Data: 885223-63-2(Hazardous Substances Data)

Usage

General Description

5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide is a chemical compound with a complex molecular structure. It is a carboxamide derivative of pyridine and contains bromine, chlorine, methoxy, and methyl functional groups. 5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide is commonly used as a reagent in organic synthesis and pharmaceutical research. It exhibits potential biological activity and is a key intermediate in the preparation of various pharmaceuticals. Its unique chemical properties and versatile applications make it an important compound in the field of medicinal and organic chemistry.

Upstream product

• 29241-65-4 5-bromo-2-chloronicotinic acid 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 

Downstream Products

• 886365-47-5 1-(5-bromo-2-chloropyridin-3-yl)ethanone 
• 228251-24-9 5-bromo-2-chloropyridine-3-carbaldehyde 
• 1401731-54-1 MR⁽⁰³³⁾T₀₀₆₅₉ 
• 1552301-52-6 N-(5-(2-amino-4-methylpyrido[2,3-d]pyrimidin-6-yl)-2-methoxypyridin-3-yl)-2,4-difluorobenzenesulfonamide 
• 928653-74-1 5-bromo-2-chloro-3-(dimethoxymethyl)pyridine 

Relevant articles and documents

HPK1 ANTAGONISTS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Identification of novel 7-amino-5-methyl-1,6-naphthyridin-2(1H)-one derivatives as potent PI3K/mTOR dual inhibitors

Inhibition of the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway is one of the most intensively studied approaches to cancer therapy. Rational design led to the identification of novel 7-amino-5-methyl-1,6-naph

A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novel activator of the p53 pathway

Reactivation of the wild-type p53 pathway is one key goal aimed at developing targeted therapeutics in the cancer research field. Although most p53 protein kinases form 'p53-activating' signals, there are few kinases whose action can contribute to the inhibition of p53, as Casein kinase 1 (CK1) and Checkpoint kinase 1 (CHK1). Here we report on a pyrazolo-pyridine analogue showing activity against both CK1 and CHK1 kinases that lead to p53 pathway stabilisation, thus having pharmacological similarities to the p53-activator Nutlin-3. These data demonstrate the emerging potential utility of multivalent kinase inhibitors.