885280-68-2

Basic information

• Product Name: C-(2-O-TOLYL-THIAZOL-4-YL)-METHYLAMINE
• Synonyms: C-(2-O-TOLYL-THIAZOL-4-YL)-METHYLAMINE;2-(2-methylphenyl)-4-Thiazolemethanamine;(2-(o-Tolyl)thiazol-4-yl)methanamine
• CAS NO: 885280-68-2
• Molecular Formula: C11H12N2S
• Molecular Weight: 204.29
• Mol File: 885280-68-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 368.6±44.0 °C(Predicted)
• Appearance: /
• Density: 1.176±0.06 g/cm3(Predicted)
• PKA: 7.47±0.29(Predicted)
• CAS DataBase Reference: C-(2-O-TOLYL-THIAZOL-4-YL)-METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: C-(2-O-TOLYL-THIAZOL-4-YL)-METHYLAMINE(885280-68-2)
• EPA Substance Registry System: C-(2-O-TOLYL-THIAZOL-4-YL)-METHYLAMINE(885280-68-2)

Safety Data

• Hazardous Substances Data: 885280-68-2(Hazardous Substances Data)

Usage

General Description

C-(2-o-tolyl-thiazol-4-yl)-methylamine, also known as Tolvaptan, is a chemical compound with molecular formula C13H13N3S. It is a selective vasopressin V2-receptor antagonist used in the treatment of hyponatremia, or low levels of sodium in the blood. Tolvaptan works by increasing the excretion of water through the kidneys, helping to restore normal sodium levels in the body. It is a potent and specific inhibitor of the vasopressin-dependent water reabsorption in the kidneys, leading to increased urination and correction of hyponatremia. Tolvaptan is typically administered orally, and its use has been associated with rare cases of liver injury, so it is important to monitor liver function in patients using this medication.

Upstream product

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• 91349-33-6 4-chloromethyl-2-o-tolyl-thiazole 

Relevant articles and documents

Design, synthesis and fungicidal activity evaluation of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety

Diflumetorim is a member of pyrimidinamine fungicides that possess excellent antifungal activities. Nevertheless, as reported that the activity of diflumetorim to corn rust (Puccinia sorghi) was not ideal (EC50 = 53.26 mg/L). Herein, a series of novel pyrimidinamine derivatives containing phenyl-thiazole/oxazole moiety were designed based on our previous study and the structural characteristics of diflumetorim, synthesized and bioassayed to discover novel fungicides with excellent antifungal activities. Among these compounds, T18 gave the optimal fungicidal activity, which respectively offers control effects with EC50 values of 0.93 mg/L against P. sorghi and 1.24 mg/L against E. graminis, significantly superior to commercial fungicides diflumetorim, tebuconazole, and flusilazole. Cell cytotoxicity results suggested that compound T18 has lower toxicities than diflumetorim. Furthermore, DFT calculation indicated that the phenyl-thiazole/oxazole moiety plays an unarguable role in the improvement of activity, which will contribute to designing and developing more potent compounds in the future.