88547-15-3Relevant articles and documents
EPIDITHIODIOXOPIPERAZINE COMPOUND OR ITS DERIVATIVES, AND THE USE THEREOF
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Paragraph 387; 392-394, (2014/12/12)
The present invention relates to an epidithiodioxopiperazine derivative represented by the Chemical Formula 1 or its reduced derivative; a method for preparing a compound represented by Chemical Formula 1 having improved intracellular permeability and mim
Comparative study of synthetic approaches to 1- arylmethylenepyrazino[2,1-b]quinazoline-3,6-diones
Cledera, Pilar,Avendano, Carmen,Menendez, J. Carlos
, p. 12349 - 12360 (2007/10/03)
The transformation of 3-arylmethylenepiperazine-2,5-diones (1) into 1- arylmethylene-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-diones (2) was studied. Four synthetic methods were compared, namely direct condensation with the product of the reaction be
Synthesis, Antibacterial Activities, and Pharmacological Properties of Enantiomers of Temafloxacin Hydrochloride
Chu, Daniel T. W.,Nordeen, Carl W.,Hardy, Dwight J.,Swanson, Robert N.,Giardina, William J.,et al.
, p. 168 - 174 (2007/10/02)
Temafloxacin hydrochloride is a potent member of the 4-pyridone-3-carboxylic acid class of antibacterial agents and is currently under clinical development as a broad-spectrum antimicrobial agent.It is a racemate having a chiral center at the C3 of the 7-piperazin-1-yl group.The two enantiomers were synthesized and tested for their antibacterial activities.Although no difference in in vitro antibacterial activities was observed, a minor difference in in vivo antibacterial activities was observed.However, they both exhibited similar pharmacological profiles.