88579-29-7

Basic information

• Product Name: 4-[(1E)-2-(4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)prop-1-en-1-yl]benzoic acid
• Synonyms: benzoic acid, 4-[(1E)-2-(3,4-dihydro-4,4-dimethyl-2H-1-benzopyran-6-yl)-1-propen-1-yl]-
• CAS NO: 88579-29-7
• Molecular Formula: C₂₁H₂₂O₃
• Molecular Weight: 322.3976
• Mol File: 88579-29-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 485.9°C at 760 mmHg
• Flash Point: 170.4°C
• Density: 1.146g/cm³
• Vapor Pressure: 2.95E-10mmHg at 25°C
• Refractive Index: 1.605
• CAS DataBase Reference: 4-[(1E)-2-(4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)prop-1-en-1-yl]benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(1E)-2-(4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)prop-1-en-1-yl]benzoic acid(88579-29-7)
• EPA Substance Registry System: 4-[(1E)-2-(4,4-dimethyl-3,4-dihydro-2H-chromen-6-yl)prop-1-en-1-yl]benzoic acid(88579-29-7)

Safety Data

• Hazardous Substances Data: 88579-29-7(Hazardous Substances Data)

Upstream product

• 88579-28-6 ethyl p-[(E)-2-(4,4-dimethyl-6-chromanyl)propenyl]-benzoate 
• 7170-38-9 3-phenoxypropanoic acid 
• 7497-89-4 methyl 3-phenoxypropanoate 
• 88579-22-0 [1-(4,4-dimethyl-6-chromanyl)ethyl]triphenylphosphonium bromide 
• 88579-19-5 4,4-Dimethylchroman-6-yl Methyl Ketone 
• 88579-20-8 4,4-dimethyl-6-(1-hydroxyethyl)-chromane 
• 87077-92-7 2-methyl-4-phenoxy-2-butanol 
• 763-32-6 2-methyl-1-buten-4-ol 
• 3350-78-5 3,3-Dimethylacryloyl chloride 
• 29598-22-9 4,4-dimethyl-2-oxo-chroman 
• 42007-25-0 diphenyl 3-methyl-3-buten-1-yl phosphate 
• 40614-20-8 3-(2'-Hydroxyphenyl)-3,3-dimethylpropanol 
• 54897-52-8 phenyl 3,3-dimethylacrylate 
• 108-95-2 phenol 

Downstream Products

• 96524-48-0 N-[5-Tetrazolyl]-4-[(E)-2-(4,4-dimethyl-6-chromanyl)-2-methylvinyl]benzamid 

Relevant articles and documents

Method for inhibiting the degradation of cartilage

Certain carboxylic acids of the formula STR1 and the pharmaceutically-acceptable salts thereof, and certain esters and amides thereof, are useful for inhibiting the degradation of articular cartilage when administered to a mammalian subject afflicted with

Heterocyclic compounds

Novel p-[2(4,4-dimethyl-6-heterophenyl)substituted phenyl derivatives and salts thereof which are useful for combatting neoplasms and dermatoses including oral and topical compositions containing said derivatives which are suitable for such uses.

Conformationally Restricted Retinoids

A series of conformationally restricted retinoids was synthesized and screened in two assays used to measure the ability of retinoids to control cell differentiation, namely, the reversal of keratinization in tracheal organ culture from vitamin A deficient hamsters and the inhibition of the induction of mouse epidermal ornithine decarboxylase by a tumor promoter.These compounds had bonds corresponding to selected bonds of the E-tetraene chain of retinoic acid (1) held in a planar cisoid conformation by inclusion in an aromatic ring.The meta-substituted analogue 3 of 4-benzoic acid (2) was far less active than 2 in both assays.In contrast, the vinyl homologue of 2 (4) and the 7,8-dihydro and 7,8-methano analogues (5 and 6) had activity comparable to that of 2.Analogues of 4-benzoic acid (7) were also screened.Replacement of the tetrahydronaphthalene ring of 7 by a benzonorbornenyl group (9) significantly reduced activity, as did removal of the vinylic methyl group from 9 (10).Replacement of the propenyl group of 9 by a cyclopropane ring (12) also reduced activity.Replacement of the tetrahydronaphthalene ring of 7 by 4,4-dimethyl-3,4-dihydro-2H-1-benzopyran and -benzothiopyran rings (13 and 14) also decreased activity.Inclusion of the 7,9 double bond system of 1 in an aromatic ring (15 and 16) reduced activity, whereas inclusion of the 5,7 double bond system in an aromatic ring enhanced activity (7 and 19).Inclusion of the 11,13 and 9,11,13 double bond systems in aromatic rings (2 and 18) also reduced activity below that of 1.Retinoic acid, 7, 13, 14, and 19 inhibited papilloma tumor formation in mice.Toxicity testing indicated that 7 was more toxic than 1, 13, 14, and 19, 19 was more toxic than 1, and 13 and 14 were less toxic than 1.