88585-32-4

Basic information

• Product Name: 1H-Pyrazole-4-carboxylic acid, 2,5-dihydro-5-oxo-1-phenyl-, ethyl ester
• CAS NO: 88585-32-4
• Molecular Formula: C12H12N2O3
• Molecular Weight: 232.239
• Mol File: 88585-32-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-4-carboxylic acid, 2,5-dihydro-5-oxo-1-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-4-carboxylic acid, 2,5-dihydro-5-oxo-1-phenyl-, ethyl ester(88585-32-4)
• EPA Substance Registry System: 1H-Pyrazole-4-carboxylic acid, 2,5-dihydro-5-oxo-1-phenyl-, ethyl ester(88585-32-4)

Safety Data

• Hazardous Substances Data: 88585-32-4(Hazardous Substances Data)

Upstream product

• 100-63-0 phenylhydrazine 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 49597-05-9 propene-1,1,3,3-tetracarboxylic acid tetraethyl ester 
• 5418-02-0 (phenylhydrazono-methyl)-malonic acid diethyl ester 

Downstream Products

• 41927-58-6 ethyl 2,3-dihydro-1-methyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxylate 
• 88585-33-5 1-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid 
• 876-92-6 2-phenyl-2,4-dihydro-pyrazol-3-one 
• 7456-81-7 2-phenyl-1,2-dihydro-pyrazol-3-one 

Relevant articles and documents

ACSS2 INHIBITORS AND METHODS OF USE THEREOF

The present invention relates to novel ACSS2 inhibitors having activity as anti-cancer therapy, treatment of alcoholism, and viral infection (e.g., CMV), composition and methods of preparation thereof, and uses thereof for treating viral infection, alcoho

Synthesis and biological evaluation of some new aryl pyrazol-3-one derivatives as potential hypoglycemic agents

Several new aryl substituted pyrazol-3-one 3 derivatives were prepared by the reaction of substituted phenyl hydrazine 1 with diethylethoxymethylene malonate (DEEM) 2. The compounds were synthesized by Michael addition reaction, which is a nucleophilic addition of enolate anions to the carbon-carbon double bond of α,β-unsaturated carboxylic acid derivatives. All the compounds were characterized by UV, IR and NMR spectroscopy and tested for hypoglycemic activity on alloxan induced diabetic rats. Among the tested compounds ethyl-2-para nitrophenyl-2,3-dihydro-1H-pyrazol-3-one-4-carboxylate 3c and ethyl-2-meta nitrophenyl-2,3-dihydro-1H-pyrazol-3-one-4-carboxylate 3d are identified as potent hypoglycemic agents and their activities are comparable with the standard drug metformin.