88621-47-0

Basic information

• Product Name: Carbamic acid, [2-oxo-2-(1-piperidinyl)ethyl]-, 1,1-dimethylethyl ester
• CAS NO: 88621-47-0
• Molecular Formula: C12H22N2O3
• Molecular Weight: 242.318
• Mol File: 88621-47-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [2-oxo-2-(1-piperidinyl)ethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [2-oxo-2-(1-piperidinyl)ethyl]-, 1,1-dimethylethyl ester(88621-47-0)
• EPA Substance Registry System: Carbamic acid, [2-oxo-2-(1-piperidinyl)ethyl]-, 1,1-dimethylethyl ester(88621-47-0)

Safety Data

• Hazardous Substances Data: 88621-47-0(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 36016-38-3 tert-Butyl N-hydroxycarbamate 
• 40052-13-9 mono-tert-butyl malonate 
• 31954-27-5 N-(tert-butoxycarbonyl)glycine methyl ester 

Downstream Products

• 5437-48-9 2-amino-1-(piperidin-1-yl)ethan-1-one hydrochloride 
• 116005-79-9 N-cyclohexyl-N-methyl-4-[2-amino-3-(1-piperidinylcarbonylmethyl)-3,4-dihydroquinazolin-6-yl]oxybutyramide hydrobromide 
• 88621-30-1 Boc-Glyt-Phe-Leu-OBzl 
• 88621-34-5 Boc-Glyt-Gly-Phe-Leu-OBzl 
• 5649-08-1 2-amino-1-(piperidin-1-yl)ethan-1-one 

Relevant articles and documents

O-Acyl isopeptide method: Development of an O-acyl isodipeptide unit for Boc SPPS and its application to the synthesis of Aβ1-42 isopeptide

The O-acyl isopeptide method was developed for the efficient preparation of difficult sequence-containing peptide. Furthermore, development of the O-acyl isodipeptide unit for Fmoc chemistry simplified its synthetic procedure by solid-phase peptide synthesis. Here, we report a novel isodipeptide unit for Boc chemistry, and the unit was successfully applied to the synthesis of amyloid β peptide. Combination of Boc chemistry and the isodipeptide unit would be an effective method for the synthesis of many difficult peptides. Copyright

Base catalytic decarboxylation amination preparation method of amino-acid ester/amide

The invention discloses a base catalytic preparation method of alpha amino-acid ester/amide from beta carbonyl acid, and belongs to the field of organic chemistry. According to the method, malonate is taken as a raw material, single hydrolysis is carried out to obtain beta carbonyl acid, reaction with a hydroxylamine compound is carried out to obtain an acyloxyl carbamic acid ester, and under the effect of an alkali, removing of one molecule carbon dioxide is carried out so as to obtain an alpha amino-acid ester, wherein the process of synthesis of the alpha amino-acid ester/amide is similar to the above process. The raw materials are widely available; operation is simple and convenient; reaction conditions are mild; using of toxic cyanide and derivatives of cyanide, strong oxidizing/reducing agents, and precious metal catalysts in a conventional alpha amino acid synthesis method is avoided; and requirements of the trend of green chemistry development are satisfied.