886366-28-5

Basic information

• Product Name: 2?N,N?dibenzylamino?5?bromopyrimidine
• Synonyms: 2?N,N?dibenzylamino?5?bromopyrimidine
• CAS NO: 886366-28-5
• Molecular Weight: 354.249
• Mol File: 886366-28-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2?N,N?dibenzylamino?5?bromopyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2?N,N?dibenzylamino?5?bromopyrimidine(886366-28-5)
• EPA Substance Registry System: 2?N,N?dibenzylamino?5?bromopyrimidine(886366-28-5)

Safety Data

• Hazardous Substances Data: 886366-28-5(Hazardous Substances Data)

Upstream product

• 7752-82-1 5-bromo-2-aminopyrimidine 
• 100-39-0 benzyl bromide 

Relevant articles and documents

Introducing a potential lead structure for the synthesis of more specific inhibitors of tyrosinases and catechol oxidases

Based on tyrosinase inhibition science, two pyrimidine derivatives were designed and studied. Docking of 2-dibenzylamine-5-hydroxy pyrimidine (dba5HP) and 2-benzylamino-5-hydroxy pyrimidine (ba5HP) on mushroom tyrosinase (MT) showed that the former could not occupy MT active site pocket, while ba5HP could do so (Moldock score = ? 63.95). MD simulation revealed that the complex of ba5HP-MT reached stability 50 = 32.28, Ki = 11.32?μM). Considering the facile synthesis, potential for structural modifications, and passing most of the lead-likeness filters, it seems likely that ba5HP plays key roles in the syntheses of novel depigmentation medicines as well as more specific inhibitors for various tyrosinases and polyphenol oxidases.