886500-49-8

Basic information

• Product Name: 2-METHOXY-4-(TRIFLUOROMETHYL)BENZOYL CHLORIDE
• Synonyms: 2-METHOXY-4-(TRIFLUOROMETHYL)BENZOYL CHLORIDE
• CAS NO: 886500-49-8
• Molecular Formula: C₉H₆ClF₃O₂
• Molecular Weight: 238.59
• Mol File: 886500-49-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 271.2±40.0 °C(Predicted)
• Appearance: /
• Density: 1.376±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-METHOXY-4-(TRIFLUOROMETHYL)BENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-4-(TRIFLUOROMETHYL)BENZOYL CHLORIDE(886500-49-8)
• EPA Substance Registry System: 2-METHOXY-4-(TRIFLUOROMETHYL)BENZOYL CHLORIDE(886500-49-8)

Safety Data

• Hazardous Substances Data: 886500-49-8(Hazardous Substances Data)

Upstream product

• 448-36-2 2-methoxy-4-(trifluoromethyl)-benzoic acid 

Downstream Products

• 1236303-20-0 2-(2-methoxy-4-trifluoromethyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole 
• 1236303-24-4 2-(2-methoxy-3-methyl-4-trifluoromethyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole 
• 1268726-24-4 2-methoxy-3-methyl-4-trifluoromethyl-benzoic acid 
• 1268726-25-5 2-(2-methoxy-3-methyl-4-trifluoromethyl-phenyl)-3,4,4-trimethyl-4,5-dihydro-oxazol-3-ium iodide 
• 1236303-14-2 2-Isopropyl-4-trifluoromethyl-benzoic acid 
• 1268726-33-5 2-(2-isopropyl-4-trifluoromethyl-phenyl)-4,4-dimethyl-4,5-dihydro oxazole 
• 1268726-34-6 2-(2-isopropyl-4-trifluoromethyl-phenyl)-3,4,4-trimethyl-4,5-dihydro-oxazol-3-ium iodide 
• 1236303-22-2 N-(2-hydroxy-1,1-dimethyl-ethyl)-2-methoxy-4-trifluoro-methyl-benzamide 
• 1236303-26-6 2-(2-ethyl-3-methyl-4-trifluoromethyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole 
• 1558680-93-5 rac-2-methoxy-N-(1-methyl-3-phenyl-piperidin-3-yl)-4-trifluoromethyl-benzamide 

Relevant articles and documents

One-Pot Domino Friedel-Crafts Acylation/Annulation between Alkynes and 2-Methoxybenzoyl Chlorides: Synthesis of 2,3-Disubstituted Chromen-4-one Derivatives

A highly regioselective synthesis of 2,3-disubstituted chromen-4-one derivatives is accomplished from readily available internal alkynes and 2-methoxybenzoyl chlorides. The reaction proceeds via a domino intermolecular Friedel-Crafts acylation/intramolecular vinyl carbocation trapping (or oxa-Michael addition)/demethylation reaction sequence. This Lewis acid promoted method features relatively mild reaction conditions to synthesize a variety of 2,3-disubstituted chromen-4-one derivatives in one pot with up to 93% yield. The chromen-2-one (coumarin) product was obtained when 2,6-dimethoxybenzoyl chloride was used as a starting material via an electrophilic aromatic substitution/rearrangement process.