886588-63-2 Usage
Description
1H-Purine-2,6-dione, 7-(2-butyn-1-yl)-8-[(3R)-3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-piperidinyl]-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]is a complex organic compound with a unique molecular structure. It is characterized by the presence of a 1H-purine-2,6-dione core, a 2-butyn-1-yl group at the 7th position, and a 3R-3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-piperidinyl group at the 8th position. Additionally, it features a 3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl] moiety. 1H-Purine-2,6-dione, 7-(2-butyn-1-yl)-8-[(3R)-3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-piperidinyl]-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]has potential applications in various fields due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
1H-Purine-2,6-dione, 7-(2-butyn-1-yl)-8-[(3R)-3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-piperidinyl]-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]is used as a reactant for preparing Linagliptin intermediate, which is further used for preparing a dipeptidyl peptidase-4 (DPP-IV) inhibitor. DPP-IV inhibitors are important drugs used in the treatment of type 2 diabetes, as they help to increase the levels of incretin hormones, which stimulate insulin release and decrease glucose production in the liver.
Check Digit Verification of cas no
The CAS Registry Mumber 886588-63-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,6,5,8 and 8 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 886588-63:
(8*8)+(7*8)+(6*6)+(5*5)+(4*8)+(3*8)+(2*6)+(1*3)=252
252 % 10 = 2
So 886588-63-2 is a valid CAS Registry Number.
886588-63-2Relevant articles and documents
A preparation method of advantage geleg sandbank (by machine translation)
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Paragraph 0048; 0049, (2018/08/03)
The invention relates to a preparation method of Linagliptin. According to the preparation method, potassium carbonate or sodium carbonate is taken as an alkali; an iodine-containing inorganic salt is taken as a catalyst; N-methyl-2-pyrrolidone (NMP) or N,N-Dimethylformamide (DMF) is taken as a solvent; 8-bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione is reacted with a (R)-3-aminopiperidine compound firstly at 40 to 50 DEG C; after reaction, 2-(chloromethyl)-4-methylquinazoline is directly added for reaction so as obtain a compound D; and the compound D is subjected to step 1-2 to prepare Linagliptin. The preparation method is capable of shortening reaction time, and increasing yield.
METHOD FOR PREPARING AN IMPORTANT INTERMEDIATE OF LINAGLIPTIN
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, (2015/12/20)
The present invention discloses an improved process for preparing an important intermediate of linagliptin. In particular, disclosed are a process for preparing a compound V which is an important intermediate of linagliptin and has the structure V, and an industrial process of preparing linagliptin having excellent chemical and optical purities, which is an inhibitor of dipeptidyl peptidase-4 (DPP-IV), from the compound V. The process employs a phase-transfer catalyst, is high in yield, easy and simple to handle, environmentally friendly, suitable for industrial mass production, and can be implemented by a “one-pot process”.
