886980-65-0

Basic information

• Product Name: Pyridine, 2-(methoxymethyl)-5-(phenylmethoxy)-
• CAS NO: 886980-65-0
• Molecular Formula: C14H15NO2
• Molecular Weight: 229.279
• Mol File: 886980-65-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Pyridine, 2-(methoxymethyl)-5-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-(methoxymethyl)-5-(phenylmethoxy)-(886980-65-0)
• EPA Substance Registry System: Pyridine, 2-(methoxymethyl)-5-(phenylmethoxy)-(886980-65-0)

Safety Data

• Hazardous Substances Data: 886980-65-0(Hazardous Substances Data)

Upstream product

• 124-41-4 sodium methylate 
• 127590-90-3 3-(benzyloxy)-6-(chloromethyl)pyridine 
• 74-83-9 methyl bromide 
• 59781-11-2 (5-(benzyloxy)pyridin-2-yl)methanol 
• 74-88-4 methyl iodide 

Downstream Products

• 944445-55-0 6-(benzyloxy)-1-methoxy-2-methylindolizine 
• 859538-90-2 5-hydroxy-2-(methoxymethyl)pyridine 

Relevant articles and documents

THIAZOLIDINONE COMPOUNDS AND USE THEREOF

A pharmaceutical composition containing a compound of Formula (I) for treating an opioid receptor-associated condition. Also disclosed is a method for treating an opioid receptor-associated condition using such a compound. Further disclosed are two sets of thiazolidinone compounds of formula (I): (i) compounds each having an enantiomeric excess greater than 90% and (ii) compounds each being substituted with deuterium.

OXOTETRAHYDROFURAN-2-YL-BENZIMIDAZOLE DERIVATIVE

The present invention relates to compounds, which are useful for treatment and/or prevention of diabetes mellitus, diabetes mellitus complications or obesity, since the compounds have glucokinase-activating effects, and are presented in Formula (I): wherein R1 represents a carbamoyl group; R2 represents a lower alkyl group; both of X1 and X2 represent CH, or any one of X1 and X2 represents a nitrogen atom and the other represents CH; a group of represents a group selected from the group consisting of a pyridinyl, a pyrazinyl, a pyrazolyl, a thiadiazolyl, a triazolyl, an isoxazolyl and a thiazolyl group; and k is zero or 1, or relates to pharmaceutically acceptable salts thereof.

Enantioselective Pd-catalyzed α-arylation of N-Boc-pyrrolidine: The key to an efficient and practical synthesis of a glucokinase activator

(Chemical Equation Presented) A short and practical synthesis of glucokinase activator 1 was achieved utilizing a convergent strategy involving SNAr coupling of activated aryl fluoride 11 with hydroxypyridine 9. The key to the success of the synthesis was the development of a novel method for enantioselective formation of α-arylpyrrolidines during the course of the project. In this method, (-)-sparteine-mediated enantioselective lithiation of N-Boc-pyrrolidine was followed by in situ transmetalation to zinc and Pd-catalyzed coupling with aryl bromide 3, proceeding in 92% ee. This transformation allowed the preparation of compound 1 in a 31% overall yield over six steps.